ceramide
Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid joined by an amide bond. Ceramides are found in high concentrations within the cell membrane of eukaryotic cells, since they are component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer. Contrary to previous assumptions that ceramides and other sphingolipids found in cell membrane were purely supporting structural elements, ceramide can participate in a variety of cellular signaling: examples include regulating differentiation, proliferation, and programmed cell death (PCD) of cells. — Wikipedia
Clinical trial activity
7 trials · 16 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2001 (NCT00008320)
Timeline
Indications
Mechanism of action
- Apoptosis regulator BAXINHIBITOR
BAX inhibitor
Chemistry & pharmacology
SMILES
CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O- Mol. weight
- 343.55 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCeramide ↗
- ChEMBLCHEMBL155886 ↗
Also known as
- ceramide
- ceramide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07066150 | N/A | Feb 6, 2025 | Government of China, SGS Life Sciences |
| NCT05101421 | N/A | Sep 1, 2021 | JScience Consultancy PLT, Nexus Wise Sdn Bhd, UCSI University |
| NCT04716452 | Phase 1 | Feb 15, 2021 | Keystone Nano, Inc, Memorial Sloan-Kettering Cancer Center, Pennsylvania State University, University of Virginia |
| NCT04249128 | Phase 3 | Jan 15, 2020 | Noho Health, ProofPilot |
| NCT04185025 | N/A | Sep 20, 2019 | Peking University |
| NCT02834611 | Phase 1 | Mar 15, 2017 | Keystone Nano, Inc, National Cancer Institute (NCI), National Institutes of Health (NIH), University of Maryland |
| NCT00008320 | Phase 2 | Jan 1, 2001 | Mayo Clinic, National Cancer Institute (NCI) |
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Keystone Nano, Inc | For profit | 2 | 2 | 1 | 2017 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 2 | 2001 |
| Government of China | Government | 1 | 1 | 1 | 2025 |
| JScience Consultancy PLT | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2001 |
| Memorial Sloan-Kettering Cancer Center | Academic/Hospital | 1 | 0 | 1 | 2021 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2017 |
| Nexus Wise Sdn Bhd | For profit | 1 | 1 | 1 | 2021 |
| Noho Health | For profit | 1 | 0 | 1 | 2020 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Pennsylvania State University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| ProofPilot | For profit | 1 | 1 | 1 | 2020 |
| SGS Life Sciences | For profit | 1 | 0 | 1 | 2025 |
| UCSI University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Maryland | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Virginia | Academic/Hospital | 1 | 0 | 1 | 2021 |