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carbetocin

Trade name: Pabal

Small moleculeexperimental

Carbetocin, sold under the brand names Pabal among others, is a medication used to prevent excessive bleeding after childbirth, particularly following Cesarean section. It appears to work as well as oxytocin. Due to it being less economical than other options, use is not recommended by NHS Scotland. It is given by injection into a vein or muscle. — Wikipedia

Clinical trial activity

79 trials · 60 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
14
Phase 3
12
Phase 4
31

Earliest trial started Nov 1, 2006 (NCT00499005)

Timeline

2010s

  1. Jan 1, 2012

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2012

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2015

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Oxytocin receptorAGONIST

    OXTR agonist

    Carbetocin is a long-acting synthetic octapeptide analogue of oxytocin with agonist properties. Like oxytocin, carbetocin binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions and increased uterine tone.

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
Mol. weight
988.18 g/mol
Lipinski Ro5
3 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-butanoic acid-2-(o-methyl-l-tyrosine)-1-carbaoxytocin
  • 1-butyric acid-2-(3-(p-methoxyphenyl)-l-alanine)oxytocin
  • 1-butyric acid-2-(3-(p-methoxyphenyl)-l-alanine)oxytocin
  • 1-carbaoxytocin, 1-butanoic acid-2-(o-methyl-l-tyrosine)-
  • 1-deamino-1-monocarba-2-(tyr(ome))-oxytocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocin
  • carbetocino
  • carbetocino
  • carbetocinum
  • carbetocinum
  • dcomot
  • deamino-2-o-methyltyrosine-1-carbaoxytocin
  • depotocin
  • depotocin
  • duratocin
  • duratocin
  • duratocin
  • fe 992097
  • oxytocin, 1-desamino-1-monocarba-(tyr(ome))(2)-
  • oxytocin, 1-desamino-1-monocarba-(tyrosine(o-methyl))(2)-
  • pabal
  • pabal
  • pabal
  • pabal
  • pabal

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07187544N/ASep 30, 2025Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada
NCT06930391N/ASep 15, 2025Icahn School of Medicine at Mount Sinai
NCT06946589Phase 4Aug 1, 2025Queen's University, Belfast
NCT06333340N/AOct 31, 2024Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada
NCT06285409N/AApr 4, 2024Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada
NCT06420297Phase 3Mar 11, 2024Acadia Pharmaceuticals
NCT06173531Phase 3Nov 27, 2023Acadia Pharmaceuticals
NCT06217354Phase 1/Phase 2 (Phase 2)Jul 6, 2023Cairo University
NCT05924321Phase 1May 25, 2023Ferring
NCT05806307Phase 4Mar 15, 2023Cairo University
NCT05742854Phase 4Mar 9, 2023Ege University
NCT05986266Phase 1Feb 1, 2023Cairo University
NCT05664659Phase 4Dec 31, 2022Ain Shams University
NCT05467462N/AAug 1, 2022Bezmialem University
NCT05479357N/AJul 28, 2022Sohag University
NCT05266534N/ADec 30, 2021Wael El-Banna Clinic Cairo Egypt
NCT05110482Phase 4Nov 30, 2021Cairo University
NCT04902729N/AJul 20, 2021Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada
NCT04595812Phase 4Nov 1, 2020Cairo University
NCT04482959Phase 4Jul 15, 2020Mansoura University
Showing 20 of 79 trials
Page 1 / 4

Organizations

Research & Development (60)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Cairo UniversityAcademic/Hospital161342011
Icahn School of Medicine at Mount SinaiAcademic/Hospital141412010
Aswan UniversityAcademic/Hospital6612018
Mount Sinai Hospital, CanadaAcademic/Hospital6012018
Ain Shams UniversityAcademic/Hospital5422012
Beni Suef UniversityAcademic/Hospital3312014
FerringFor profit3232014
University of BernAcademic/Hospital3322013
Acadia PharmaceuticalsFor profit2212023
Assiut UniversityAcademic/Hospital2112012
Osaka UniversityAcademic/Hospital2212009
Sohag UniversityAcademic/Hospital2212012
University of British ColumbiaAcademic/Hospital2212016
University of OsloAcademic/Hospital2112015
Al Azhar UniversityAcademic/Hospital1012012
Al- Elweyia Maternity Teaching HospitalAcademic/Hospital1012018
assistant profossorAcademic/Hospital1012013
Bangladesh Medical UniversityAcademic/Hospital1112015
Benha UniversityAcademic/Hospital1112013
Bezmialem UniversityAcademic/Hospital1112022
60 organizations
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