tozadenant
Small moleculeexperimental
Clinical trial activity
8 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
3
Phase 3
3
Phase 4
0
Earliest trial started Apr 1, 2008 (NCT00605553)
Timeline
Indications
Mechanism of action
- Adenosine A2a receptorANTAGONIST
ADORA2A antagonist
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12- Mol. weight
- 406.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2105747 ↗
Also known as
- a2a
- a2a
- ro-4494351
- ro-4494351
- ro-4494351000
- ro-4494351000
- ro-4494351-002
- ro-4494351-002
- syn115
- syn115
- syn115
- syn-115
- syn-115
- tozadenant
- tozadenant
- tozadenant
- tozadenant
- tozadenant
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03200080 | Phase 1 | Sep 18, 2017 | Acorda Therapeutics, Biotie Therapies, INC Research |
| NCT03212313 | Phase 1 | Jun 30, 2017 | Acorda Therapeutics, Biotie Therapies, University of Miami |
| NCT03051607 | Phase 3 | Apr 30, 2017 | Acorda Therapeutics, Biotie Therapies |
| NCT02453386 | Phase 3 | Jul 1, 2015 | Biotie Therapies |
| NCT02240290 | Phase 1 | Sep 1, 2013 | Biotie Therapies, Pharmaceutical Research Associates, Inc. (PRA), Tandem Labs, Xceleron Inc |
| NCT01283594 | Phase 2/Phase 3 (Phase 3) | Mar 1, 2011 | Biotie Therapies |
| NCT00783276 | Early Phase 1 (Phase 1) | Oct 1, 2008 | National Institute on Drug Abuse (NIDA), University of Texas at Houston, Virginia Commonwealth University |
| NCT00605553 | Phase 2 | Apr 1, 2008 | Biotie Therapies, Synosia Therapeutics, Washington University in St. Louis |
Showing 8 of 8 trials
Page 1 / 1
Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Biotie Therapies | For profit | 7 | 7 | 3 | 2008 |
| Acorda Therapeutics | For profit | 3 | 0 | 2 | 2017 |
| INC Research | For profit | 1 | 0 | 1 | 2017 |
| National Institute on Drug Abuse (NIDA) | Government | 1 | 0 | 1 | 2008 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2013 |
| Synosia Therapeutics | For profit | 1 | 0 | 1 | 2008 |
| Tandem Labs | For profit | 1 | 0 | 1 | 2013 |
| University of Miami | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Virginia Commonwealth University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Washington University in St. Louis | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Xceleron Inc | For profit | 1 | 0 | 1 | 2013 |
12 organizations
Page 1 / 1