brostallicin
Small moleculeexperimental
Brostallicin is a chemical compound being studied in the treatment of cancer. It is an alkylating agent that binds DNA. — Wikipedia
Clinical trial activity
5 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2002 (NCT00041249)
Timeline
Indications
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
C=C(Br)C(=O)Nc1cc(C(=O)Nc2cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCNC(=N)N)n(C)c4)n(C)c3)n(C)c2)n(C)c1- Mol. weight
- 723.59 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBrostallicin ↗
- ChEMBLCHEMBL1189025 ↗
Also known as
- brostallicin
- brostallicin
- brostallicin
- brostallicin
- pnu166196
- pnu 166196
- pnu-166196
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01091454 | Phase 2 | Jun 1, 2010 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT00633165 | Phase 2 | Aug 1, 2007 | CTI BioPharma, Systems Medicine LLC |
| NCT00410462 | Phase 2 | Oct 1, 2006 | European Organisation for Research and Treatment of Cancer, Leiden University |
| NCT00060203 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2002 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00041249 | Phase 2 | May 1, 2002 | European Organisation for Research and Treatment of Cancer, University of Western Australia |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 2 | 2 | 1 | 2002 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 1 | 2002 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2002 |
| CTI BioPharma | For profit | 1 | 0 | 1 | 2007 |
| Leiden University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Systems Medicine LLC | For profit | 1 | 1 | 1 | 2007 |
| University of Western Australia | Academic/Hospital | 1 | 0 | 1 | 2002 |
8 organizations
Page 1 / 1