umirolimus
Trade name: Biolimus
Small moleculeexperimental
Umirolimus is an immunosuppressant, a macrocyclic lactone, a highly lipophilic derivative of sirolimus. This drug is proprietary to Biosensors International, which uses it in its own drug-eluting stents, and licenses it to partners such as Terumo. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
4
Earliest trial started Jul 1, 2010 (NCT01502904)
Timeline
No events for the selected filters.
Indications
Approved for
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
CCOCCO[C@@H]1CC[C@@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C(\C)[C@@H](OC)C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)C[C@H]1OC- Mol. weight
- 986.29 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaUmirolimus ↗
- ChEMBLCHEMBL2107380 ↗
Also known as
- 40-o-(2-ethoxyethyl)rapamycin
- 42-o-(2-ethoxyethyl) rapamycin
- biolimus
- biolimus
- biolimus a9
- rapamycin, 42-o-(2-ethoxyethyl)-
- trm-986
- umirolimus
- umirolimus
- umirolimus
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02446730 | Phase 4 | Sep 1, 2014 | Chonnam National University |
| NCT02193971 | Phase 4 | Jul 1, 2014 | Boston Scientific Corporation, Seoul National University, Terumo Corporation |
| NCT03056118 | Phase 4 | May 2, 2011 | Yonsei University |
| NCT01502904 | Phase 4 | Jul 1, 2010 | Yonsei University |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Yonsei University | Academic/Hospital | 2 | 2 | 1 | 2010 |
| Boston Scientific Corporation | For profit | 1 | 0 | 1 | 2014 |
| Chonnam National University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Terumo Corporation | For profit | 1 | 0 | 1 | 2014 |
5 organizations
Page 1 / 1