Inactivated polio virus - Enhanced
Trade name: IPOL
Vaccineapproved
Approved
Dec 21, 1990
Clinical trial activity
104 trials · 71 clinical orgs · 0 marketing orgs
Phase 1
13
Phase 2
61
Phase 3
44
Phase 4
35
Earliest trial started Sep 1, 1998 (NCT01457495)
Timeline
Indications
Approved for
Studied for
- Apnea · Phase 4
- Communicable Diseases · Phase 2
- Diphtheria · Phase 4
- Diphtheria-Tetanus-Pertussis Vaccine · Phase 4
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Gastroenteritis · Phase 3
- Haemophilus influenzae · Phase 3
- Haemophilus influenzae type b · Phase 4
- Healthy Volunteers · Phase 4
- Hepatitis A · Phase 4
- Hepatitis B · Phase 4
- Hospitalization · Phase 4
- Human papillomavirus 16 · Phase 4
- Immunization · Phase 4
- Immunization, Secondary · Phase 1/Phase 2
- Infant, Premature, Diseases · Phase 4
- Influenza, Human · Phase 4
- Measles · Phase 4
- Measles-Mumps-Rubella Vaccine · Phase 4
- Meningitis · Phase 3
- Meningitis, Bacterial · Phase 3
- Meningitis, Meningococcal · Phase 3
- Meningococcal Infections · Phase 3
- Mortality · Phase 4
- Mumps · Phase 4
- Neisseria meningitidis · Phase 4
- Papillomavirus Infections · Phase 4
- Pertussis Vaccine · Phase 4
- Pneumonia, Staphylococcal · Phase 3
- Poliomyelitis · Phase 4
- Poliovirus Vaccines · Phase 2
- Rotavirus Infections · Phase 4
- Rubella · Phase 4
- Salmonella Infections · Phase 2
- SARS-CoV-2 · Phase 4
- Streptococcal Infections · Phase 4
- Tetanus · Phase 4
- Tropical Medicine · Phase 3
- Vaccination · Phase 4
- Vaccines · Phase 4
- Whooping Cough · Phase 4
Mechanism of action
- PoliovirusImmunity, active
Poliovirus immunity, active
Approval history
- approvedDec 21, 1990
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- infanrix ipv
- infanrix-ipv/hib
- ipv
- ipv
- ipv-al ssi
- ipv vaccine
- m-ipv hd
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06920069 | Phase 4 | May 15, 2025 | Chinese Academy of Medical Sciences |
| NCT06577298 | Phase 1/Phase 2 (Phase 2) | Oct 31, 2024 | Tianjin Cansino Biotechnology Inc, University of Indonesia |
| NCT06903221 | Phase 4 | Oct 16, 2024 | Radboud University |
| NCT06442449 | Phase 4 | Jul 10, 2024 | Sinovac Biotech Co., Ltd |
| NCT06460545 | Phase 4 | Jun 15, 2024 | Chinese Academy of Medical Sciences, Government of China |
| NCT06346834 | Phase 4 | Apr 30, 2024 | Government of China, Sinovac Biotech Co., Ltd |
| NCT06331156 | Phase 3 | Mar 22, 2024 | GlaxoSmithKline |
| NCT06213506 | Phase 2 | Jan 15, 2024 | GlaxoSmithKline, Kwame Nkrumah University of Science and Technology |
| NCT06101173 | Phase 1 | Dec 30, 2023 | Novotech, Nucleus Network Ltd, Tianjin Cansino Biotechnology Inc |
| NCT06114810 | Phase 4 | Nov 30, 2023 | Centers for Disease Control and Prevention (CDC), Government of Bangladesh, International Center for Diarrheal Disease Research |
| NCT06752174 | Phase 3 | Mar 8, 2023 | Beijing Minhai Biotechnology Co., Ltd |
| NCT05432141 | Phase 4 | Jun 13, 2022 | Government of China, Sinovac Biotech Co., Ltd |
| NCT05279248 | Phase 4 | Aug 25, 2021 | Government of China |
| NCT04998344 | Phase 4 | Apr 7, 2021 | International Center for Diarrheal Disease Research, Norwegian University of Science and Technology, University of Bergen |
| NCT04448132 | Phase 4 | Nov 20, 2020 | AJ Vaccines A/S |
| NCT04639375 | Phase 4 | Nov 15, 2020 | E-MO Biology |
| NCT04638985 | Phase 4 | Nov 13, 2020 | Beijing Tiantan Bio Co., Ltd, Chengdu Institute of Biological Products Co.,Ltd., China National Biotec Group Co., Ltd, Government of China, Peking University |
| NCT04636827 | Phase 4 | Nov 11, 2020 | Beijing Tiantan Bio Co., Ltd, China National Biotec Group Co., Ltd, Government of China |
| NCT04504539 | N/A | Aug 31, 2020 | Aga Khan University, World Health Organization |
| NCT04481191 | Phase 3 | Aug 25, 2020 | Merck |
Showing 20 of 104 trials
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Organizations
Research & Development (71)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 28 | 28 | 3 | 1998 |
| Bill and Melinda Gates Foundation | Academic/Hospital | 13 | 0 | 4 | 2011 |
| Centers for Disease Control and Prevention (CDC) | Government | 12 | 7 | 2 | 2011 |
| Government of China | Government | 12 | 4 | 3 | 2016 |
| International Center for Diarrheal Disease Research | Academic/Hospital | 12 | 2 | 2 | 2011 |
| Statens Serum Institut | Academic/Hospital | 6 | 6 | 2 | 2003 |
| Larix A/S | For profit | 5 | 0 | 2 | 2014 |
| Sanofi | For profit | 5 | 5 | 1 | 2005 |
| World Health Organization | Government | 5 | 0 | 4 | 2011 |
| AJ Vaccines A/S | For profit | 4 | 1 | 2 | 2017 |
| Beijing Minhai Biotechnology Co., Ltd | For profit | 4 | 2 | 3 | 2017 |
| China National Biotec Group Co., Ltd | For profit | 4 | 4 | 1 | 2018 |
| Novartis | For profit | 4 | 4 | 1 | 2007 |
| Sinovac Biotech Co., Ltd | For profit | 4 | 4 | 2 | 2016 |
| Beijing Tiantan Bio Co., Ltd | For profit | 3 | 0 | 1 | 2018 |
| Fidec Corporation | Academic/Hospital | 3 | 3 | 2 | 2013 |
| Peking University | Academic/Hospital | 3 | 0 | 1 | 2018 |
| University of Vermont | Academic/Hospital | 3 | 2 | 2 | 2011 |
| University of Virginia | Academic/Hospital | 3 | 1 | 2 | 2011 |
| Vaxtrials S.A. | For profit | 3 | 1 | 2 | 2014 |
71 organizations
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