sasanlimab
mAbexperimental
Clinical trial activity
25 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
18
Phase 2
9
Phase 3
2
Phase 4
0
Earliest trial started Dec 30, 2015 (NCT02616185)
Timeline
Indications
Studied for
- Adenocarcinoma · Phase 2
- Bile Duct Neoplasms · Phase 1
- Carcinoma · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2/Phase 3
- Carcinoma, Pancreatic Ductal · Phase 1
- Carcinoma, Renal Cell · Phase 2
- Carcinoma, Squamous Cell · Phase 1
- Carcinoma, Transitional Cell · Phase 2
- Cholangiocarcinoma · Phase 1/Phase 2
- Colorectal Neoplasms · Phase 2
- Endometrial Neoplasms · Phase 1
- Esophageal Neoplasms · Phase 1
- Food Intolerance · Phase 2
- Head and Neck Neoplasms · Phase 1
- Hodgkin Disease · Phase 1
- Intestinal Neoplasms · Phase 1
- Kidney Diseases · Phase 2
- Kidney Neoplasms · Phase 2
- Liver Neoplasms · Phase 1
- Lung Neoplasms · Phase 1
- Lymphoma · Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 1
- Lymphoma, T-Cell, Peripheral · Phase 1
- Melanoma · Phase 1
- Mesothelioma · Phase 1/Phase 2
- Mesothelioma, Malignant · Phase 1/Phase 2
- Neoplasm Metastasis · Phase 2
- Neoplasms · Phase 2
- Neoplasms by Site · Phase 2
- Neoplasms, Glandular and Epithelial · Phase 2
- Ovarian Neoplasms · Phase 1/Phase 2
- Pancreatic Neoplasms · Phase 1
- Prostatic Neoplasms · Phase 1
- Sarcoma · Phase 1
- Small Cell Lung Carcinoma · Phase 1/Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 1
- Stomach Neoplasms · Phase 1
- Urinary Bladder Neoplasms · Phase 3
- Urogenital Neoplasms · Phase 2
- Urologic Diseases · Phase 2
- Urologic Neoplasms · Phase 2
Mechanism of action
- Programmed cell death protein 1ANTAGONIST
Programmed cell death protein 1 antagonist
- 80S RibosomeINHIBITOR
80S Ribosome inhibitor
- 60S ribosomal protein L39 (RPL39) ↗
- 60S ribosomal protein L41 (RPL41) ↗
- 40S ribosomal protein S15 (RPS15) ↗
- 40S ribosomal protein S15a (RPS15A) ↗
- 40S ribosomal protein S16 (RPS16) ↗
- 40S ribosomal protein S17 (RPS17) ↗
- 40S ribosomal protein SA (RPSA) ↗
- 40S ribosomal protein S18 (RPS18) ↗
- 40S ribosomal protein S19 (RPS19) ↗
- 40S ribosomal protein S20 (RPS20) ↗
- 40S ribosomal protein S21 (RPS21) ↗
- 40S ribosomal protein S23 (RPS23) ↗
- 40S ribosomal protein S24 (RPS24) ↗
- 40S ribosomal protein S25 (RPS25) ↗
- 40S ribosomal protein S27 (RPS27) ↗
- 40S ribosomal protein S26 (RPS26) ↗
- Ubiquitin-40S ribosomal protein S27a (RPS27A) ↗
- 40S ribosomal protein S28 (RPS28) ↗
- 40S ribosomal protein S29 (RPS29) ↗
- 40S ribosomal protein S30 (RS30) ↗
- 60S ribosomal protein L21 (RPL21) ↗
- 60S ribosomal protein L22 (RPL22) ↗
- 60S ribosomal protein L23 (RPL23) ↗
- 60S ribosomal protein L23a (RPL23A) ↗
- 60S ribosomal protein L24 (RPL24) ↗
- 40S ribosomal protein S6 (RPS6) ↗
- 60S ribosomal protein L26 (RPL26) ↗
- 60S ribosomal protein L27 (RPL27) ↗
- 60S ribosomal protein L27a (RPL27A) ↗
- 60S ribosomal protein L28 (RPL28) ↗
- 60S ribosomal protein L29 (RPL29) ↗
- 60S ribosomal protein L30 (RPL30) ↗
- 60S ribosomal protein L31 (RPL31) ↗
- 60S ribosomal protein L32 (RPL32) ↗
- 60S ribosomal protein L34 (RPL34) ↗
- 60S ribosomal protein L35 (RPL35) ↗
- 60S ribosomal protein L35a (RPL35A) ↗
- 60S ribosomal protein L36 (RPL36) ↗
- 60S ribosomal protein L36a (RPL36A) ↗
- 60S ribosomal protein L37 (RPL37) ↗
- 40S ribosomal protein S10 (RPS10) ↗
- 40S ribosomal protein S11 (RPS11) ↗
- 40S ribosomal protein S12 (RPS12) ↗
- 40S ribosomal protein S13 (RPS13) ↗
- 40S ribosomal protein S14 (RPS14) ↗
- 60S ribosomal protein L37a (RPL37A) ↗
- 40S ribosomal protein S2 (RPS2) ↗
- 40S ribosomal protein S3 (RPS3) ↗
- 40S ribosomal protein S3a (RPS3A) ↗
- 40S ribosomal protein S4, X isoform (RPS4X) ↗
- 40S ribosomal protein S4, Y isoform 1 (RPS4Y1) ↗
- 40S ribosomal protein S5 (RPS5) ↗
- 40S ribosomal protein S7 (RPS7) ↗
- 40S ribosomal protein S8 (RPS8) ↗
- 40S ribosomal protein S9 (RPS9) ↗
- 60S ribosomal protein L3 (RPL3) ↗
- 60S ribosomal protein L4 (RPL4) ↗
- 60S ribosomal protein L5 (RPL5) ↗
- 60S ribosomal protein L6 (RPL6) ↗
- 60S ribosomal protein L7 (RPL7) ↗
- 60S ribosomal protein L7a (RPL7A) ↗
- 60S ribosomal protein L8 (RPL8) ↗
- 60S ribosomal protein L9 (RPL9; RPL9P7; RPL9P8; RPL9P9) ↗
- 60S ribosomal protein L10 (RPL10) ↗
- 60S ribosomal protein L10a (RPL10A) ↗
- 60S ribosomal protein L11 (RPL11) ↗
- 60S ribosomal protein L12 (RPL12) ↗
- 60S ribosomal protein L13 (RPL13) ↗
- 60S ribosomal protein L13a (RPL13A) ↗
- 60S ribosomal protein L14 (RPL14) ↗
- 60S ribosomal protein L15 (RPL15) ↗
- 60S ribosomal protein L17 (RPL17) ↗
- 60S ribosomal protein L18 (RPL18) ↗
- 60S ribosomal protein L18a (RPL18A) ↗
- 60S ribosomal protein L19 (RPL19) ↗
- 60S ribosomal protein L38 (RPL38) ↗
- 60S acidic ribosomal protein P0 (RPLP0) ↗
- 60S acidic ribosomal protein P1 (RPLP1) ↗
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4298191 ↗
Also known as
- pf-06801591
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07123090 | Phase 2 | Feb 28, 2026 | Harvard University, Pfizer |
| NCT07206225 | Phase 1 | Nov 6, 2025 | Pfizer |
| NCT06870487 | Phase 1 | May 8, 2025 | Pfizer |
| NCT06974734 | Phase 1 | May 6, 2025 | Pfizer |
| NCT06704724 | Phase 1 | Jan 13, 2025 | Pfizer |
| NCT06580938 | Phase 1 | Nov 1, 2024 | Pfizer |
| NCT06546553 | Phase 1 | Sep 6, 2024 | Pfizer |
| NCT06218069 | Phase 2/Phase 3 (Phase 3) | Aug 31, 2024 | ImaginAb, Inc., Pfizer, Radboud University, University of Tuebingen |
| NCT06448364 | Phase 1 | May 9, 2024 | Pfizer |
| NCT06285097 | Phase 1 | Feb 8, 2024 | Pfizer |
| NCT05935748 | Phase 2 | Jul 28, 2023 | NiKang Therapeutics, Inc., Pfizer |
| NCT06089265 | Phase 2 | Jun 15, 2023 | Maastricht University, Pfizer |
| NCT05665361 | Phase 1/Phase 2 (Phase 2) | Dec 29, 2022 | National Cancer Institute (NCI) |
| NCT05259397 | Phase 1 | Mar 24, 2022 | Pfizer |
| NCT05233436 | Phase 1 | Feb 24, 2022 | Pfizer |
| NCT05241340 | Phase 2 | Feb 15, 2022 | Pfizer, The University of Texas, Dallas |
| NCT05061537 | Phase 1 | Oct 20, 2021 | Pfizer |
| NCT04585815 | Phase 1/Phase 2 (Phase 2) | Nov 10, 2020 | Pfizer |
| NCT04181788 | Phase 2 | Feb 28, 2020 | Pfizer |
| NCT04165317 | Phase 3 | Dec 23, 2019 | Pfizer |
Showing 20 of 25 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 23 | 18 | 3 | 2015 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2026 |
| ImaginAb, Inc. | For profit | 1 | 0 | 1 | 2024 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2022 |
| NiKang Therapeutics, Inc. | For profit | 1 | 1 | 1 | 2023 |
| Radboud University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| TCR2 Therapeutics | For profit | 1 | 1 | 1 | 2019 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Tuebingen | Academic/Hospital | 1 | 0 | 1 | 2024 |
10 organizations
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