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ghrelin

Peptideexperimental

Ghrelin is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is often called a "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes. Ghrelin may help prepare for food intake by increasing gastric motility and stimulating the secretion of gastric acid. — Wikipedia

Clinical trial activity

39 trials · 28 clinical orgs · 0 marketing orgs

Phase 1
18
Phase 2
14
Phase 3
1
Phase 4
0

Earliest trial started Jan 1, 2003 (NCT00512525)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O
Mol. weight
3314.85 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • acyl ghrelin
  • acyl-ghrelin
  • desacylghrelin
  • des-acyl ghrelin
  • desacyl ghrelin
  • desacyl ghrelin
  • des-n-octanoyl ghrelin
  • gastric mltrp
  • ghrelin
  • ghrelin
  • ghrelin
  • ghrelin, des-n-octanoyl
  • human acylated ghrelin
  • human acylated ghrelin
  • lenomorelin
  • lenomorelin
  • sun11031

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06576440N/ASep 2, 2024University of Tuebingen
NCT05726240Phase 2Oct 31, 2023Rijnstate Hospital
NCT05318924Phase 1/Phase 2 (Phase 2)Feb 21, 2022German Research Foundation, University of Tuebingen
NCT05189353N/AJan 14, 2022University of Copenhagen
NCT04558346Phase 2Oct 20, 2020University of Kansas
NCT04377126Phase 2May 20, 2020National Institute on Aging (NIA), Northwestern University
NCT04055025N/ASep 30, 2019University of Copenhagen
NCT03198143Phase 1Mar 31, 2019Duke University
NCT02440061Phase 1May 1, 2017Duke University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02913703Phase 1Jan 11, 2017Duke University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02953587Phase 1Sep 1, 2016National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Vanderbilt University
NCT03358355Phase 1/Phase 2 (Phase 2)Jun 7, 2016Northwestern University
NCT02690987Early Phase 1 (Phase 1)Aug 1, 2015University of London
NCT02528422Phase 1May 1, 2015Aarhus University
NCT02271282Phase 1Dec 1, 2014Mayo Clinic
NCT02272647Phase 1Dec 1, 2014Mayo Clinic
NCT01898611Phase 2Jul 1, 2013University of Pennsylvania
NCT01729299N/AApr 1, 2013National Institutes of Health (NIH), University of Cincinnati
NCT05277415Phase 1/Phase 2 (Phase 2)Feb 17, 2013Karolinska Institute
NCT01833078Phase 2Feb 1, 2013University of Pennsylvania
Showing 20 of 39 trials
Page 1 / 2

Organizations

Research & Development (28)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Aarhus UniversityAcademic/Hospital7722003
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government5022011
University of PennsylvaniaAcademic/Hospital4412007
Duke UniversityAcademic/Hospital3312017
Vanderbilt UniversityAcademic/Hospital3312011
German Research FoundationAcademic/Hospital2022004
Mayo ClinicAcademic/Hospital2212014
Northwestern UniversityAcademic/Hospital2212016
University of CincinnatiAcademic/Hospital2212011
University of CopenhagenAcademic/Hospital2212019
University of TuebingenAcademic/Hospital2222022
BachemFor profit1012009
Brown UniversityAcademic/Hospital1112011
Cantonal Hospital of St. GallenAcademic/Hospital1112009
Daiichi SankyoFor profit1112008
Karolinska InstituteAcademic/Hospital1112013
Max Planck InstituteAcademic/Hospital1112004
Medical Research CouncilGovernment1012003
Monash UniversityAcademic/Hospital1112009
National Institute on Aging (NIA)Government1012020
28 organizations
Page 1 / 2