cpi-0209
Small moleculeexperimental
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Sep 18, 2019 (NCT04104776)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Endometrial Neoplasms · Phase 1/Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 1/Phase 2
- Lymphoma, T-Cell · Phase 1/Phase 2
- Mesothelioma, Malignant · Phase 1/Phase 2
- Mycosis Fungoides · Phase 1
- Neoplasms · Phase 1/Phase 2
- Ovarian Neoplasms · Phase 1/Phase 2
- Prostatic Neoplasms · Phase 1/Phase 2
- Prostatic Neoplasms, Castration-Resistant · Phase 1/Phase 2
- Sezary Syndrome · Phase 1
Mechanism of action
EZH2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COC1CN([C@H]2CC[C@H]([C@@]3(C)Oc4c(Cl)cc(C(=O)NCc5c(SC)cc(C)[nH]c5=O)c(C)c4O3)CC2)C1- Mol. weight
- 562.13 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5095231 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07190300 | Phase 1/Phase 2 (Phase 2) | Nov 24, 2025 | Novartis |
| NCT07206056 | Phase 1/Phase 2 (Phase 2) | Oct 15, 2025 | Novartis |
| NCT05942300 | Phase 1 | Dec 31, 2023 | MorphoSys, National Cancer Institute (NCI), University of Pittsburgh |
| NCT05944562 | Phase 1 | Dec 31, 2023 | MorphoSys, Novartis, Swim Across America, Washington University in St. Louis |
| NCT04104776 | Phase 1/Phase 2 (Phase 2) | Sep 18, 2019 | Constellation Pharmaceuticals |
Showing 5 of 5 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Novartis | For profit | 3 | 2 | 2 | 2023 |
| MorphoSys | For profit | 2 | 0 | 1 | 2023 |
| Constellation Pharmaceuticals | For profit | 1 | 1 | 1 | 2019 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2023 |
| Swim Across America | Academic/Hospital | 1 | 0 | 1 | 2023 |
| University of Pittsburgh | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Washington University in St. Louis | Academic/Hospital | 1 | 1 | 1 | 2023 |
7 organizations
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