levonadifloxacin
Small moleculeexperimental
Clinical trial activity
4 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
2
Phase 4
1
Earliest trial started Jan 1, 2005 (NCT00219570)
Timeline
Indications
Approved for
Mechanism of action
- DNA gyraseINHIBITOR
DNA gyrase inhibitor
- Topoisomerase IVINHIBITOR
Topoisomerase IV inhibitor
May have higher activity against DNA gyrase vs. Topoisomerase IV.
- Bacterial DNA gyraseINHIBITOR
Bacterial DNA gyrase inhibitor
May have higher activity against DNA gyrase vs. Topoisomerase IV.
Chemistry & pharmacology
Loading structure…
SMILES
C[C@H]1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23- Mol. weight
- 360.39 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL363449 ↗
- ChEMBLCHEMBL190561 ↗
Also known as
- 1h,5h-benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (+-)-
- 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1h,5h-benzo(i,j)quinolizine-2-carboxylic acid
- jinofloxacin
- nadifloxacin
- nadifloxacin
- nadifloxacin
- nadifloxacin
- nadifloxacin
- nadifloxacin
- nadifloxacin
- nadixa
- opc 7251
- opc 7251
- opc 7251
- opc 7251
- opc 7251
- opc-7251
- opc-7251
- opc-7251
- opc-7251
- r-ndfx
- s-ndfx
- wck771
- wck771
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03405064 | Phase 3 | Aug 25, 2017 | Wockhardt |
| NCT01875939 | Phase 1 | Jun 1, 2013 | PPD, Wockhardt |
| NCT00869492 | Phase 3 | Aug 1, 2008 | Marmara University |
| NCT00219570 | Phase 4 | Jan 1, 2005 | Acronet, Bellsystem24 , Inc., Mitsubishi Kagaku Bio-Clinical Laboratories, inc, Parexel, Pfizer, SACT INTERNATIONAL Co., LTD., Sato Pharmaceutical |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Wockhardt | For profit | 2 | 2 | 2 | 2013 |
| Acronet | For profit | 1 | 0 | 1 | 2005 |
| Bellsystem24 , Inc. | For profit | 1 | 0 | 1 | 2005 |
| Marmara University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Mitsubishi Kagaku Bio-Clinical Laboratories, inc | For profit | 1 | 0 | 1 | 2005 |
| Parexel | For profit | 1 | 0 | 1 | 2005 |
| Pfizer | For profit | 1 | 1 | 1 | 2005 |
| PPD | For profit | 1 | 0 | 1 | 2013 |
| SACT INTERNATIONAL Co., LTD. | For profit | 1 | 0 | 1 | 2005 |
| Sato Pharmaceutical | For profit | 1 | 0 | 1 | 2005 |
10 organizations
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