besifovir
Small moleculeexperimental
Besifovir (INN) is an investigational medication to treat hepatitis B virus (HBV) infection. It is a novel and potent acyclic nucleotide phosphonate with a similar chemical structure to adefovir and tenofovir. — Wikipedia
Clinical trial activity
10 trials · 18 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
5
Phase 3
2
Phase 4
3
Earliest trial started Mar 1, 2004 (NCT00895596)
Timeline
Indications
Approved for
Mechanism of action
- Hepatitis B virusINHIBITOR
Hepatitis B virus inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Nc1ncc2ncn(CC3(OCP(=O)(O)O)CC3)c2n1- Mol. weight
- 299.23 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBesifovir ↗
- ChEMBLCHEMBL329091 ↗
Also known as
- ((1-((2-amino-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonic acid di(pivaloyloxymethyl) ester
- ((1-((2-amino-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonic acid dipivoxyl
- besifovir
- besifovir
- besifovir
- lb80380
- lb80380
- lb-80380
- pmcdg dipivoxyl
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04249908 | Phase 1 | Feb 13, 2020 | IlDong Pharmaceutical Co Ltd |
| NCT04202536 | Phase 4 | May 29, 2019 | IlDong Pharmaceutical Co Ltd |
| NCT03885778 | Phase 4 | Jan 13, 2019 | IlDong Pharmaceutical Co Ltd, Inje University |
| NCT03604016 | Phase 4 | Sep 23, 2018 | IlDong Pharmaceutical Co Ltd |
| NCT02792088 | Phase 3 | Jul 1, 2015 | IlDong Pharmaceutical Co Ltd, Yonsei University |
| NCT01937806 | Phase 3 | Oct 1, 2013 | Ajou University, Catholic University of Korea, Chungnam National University, Hallym University, Hanyang University, IlDong Pharmaceutical Co Ltd, Inha University, Inje University, Korea University, Kyungpook University, Seoul National University, Soonchunhyang University, University of Ulsan, Wonju Christian Hospital, Yonsei University |
| NCT01427868 | Phase 1 | Sep 1, 2010 | LG, Sungkyunkwan University |
| NCT01242787 | Phase 2 | Aug 1, 2010 | LG |
| NCT01026610 | Phase 2 | Aug 1, 2009 | LG |
| NCT00895596 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2004 | LG, The University of Hong Kong |
Showing 10 of 10 trials
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Organizations
Research & Development (18)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| IlDong Pharmaceutical Co Ltd | For profit | 6 | 6 | 3 | 2013 |
| LG | For profit | 4 | 4 | 2 | 2004 |
| Inje University | Academic/Hospital | 2 | 0 | 2 | 2013 |
| Yonsei University | Academic/Hospital | 2 | 0 | 1 | 2013 |
| Ajou University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Chungnam National University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Hallym University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Hanyang University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Inha University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Kyungpook University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Seoul National University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Soonchunhyang University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Sungkyunkwan University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| The University of Hong Kong | Academic/Hospital | 1 | 0 | 1 | 2004 |
| University of Ulsan | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Wonju Christian Hospital | Academic/Hospital | 1 | 0 | 1 | 2013 |
18 organizations
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