favipiravir
Small moleculeexperimentalCOVID-19
Favipiravir, sold under the brand name Avigan among others, is an antiviral medication used to treat influenza in Japan. It is also being studied to treat a number of other viral infections, including SARS-CoV-2. Like the experimental antiviral drugs T-1105 and T-1106, it is a pyrazinecarboxamide derivative. — Wikipedia
Clinical trial activity
83 trials · 196 clinical orgs · 0 marketing orgs
Phase 1
18
Phase 2
51
Phase 3
36
Phase 4
3
Earliest trial started Feb 1, 2010 (NCT01068912)
Timeline
Indications
Approved for
Studied for
- Atrial Fibrillation · Phase 4
- Atrial Flutter · Phase 4
- Communicable Diseases · Phase 3
- Coronavirus Infections · Phase 3
- COVID-19 · Phase 4
- Critical Illness · Phase 2
- Drugs, Investigational · Phase 2/Phase 3
- Healthy Volunteers · Phase 1
- Hemorrhagic Fever, Crimean · Phase 2
- Hemorrhagic Fever, Ebola · Phase 2
- Influenza A virus · Phase 3
- Influenza, Human · Phase 3
- Lassa Fever · Phase 2/Phase 3
- Liver Diseases · Phase 1
- Pharmacology · Phase 1
- Pneumonia, Bacterial · Phase 3
- Respiratory Distress Syndrome · Phase 1/Phase 2
- Respiratory Syncytial Viruses · Phase 2
- Respiratory Syncytial Virus, Human · Phase 2
- SARS-CoV-2 · Phase 2
- Severe Acute Respiratory Syndrome · Phase 3
- Therapeutic Equivalency · Phase 1
Mechanism of action
NS5B antagonist
- Influenza A virusINHIBITOR
Influenza A virus inhibitor
- RNA-directed RNA polymeraseINHIBITOR
RNA-directed RNA polymerase inhibitor
Active against influenza A and B infections.
Catalytic subunit
Chemistry & pharmacology
Loading structure…
SMILES
NC(=O)c1nc(F)cnc1O- Mol. weight
- 157.1 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaFavipiravir ↗
- ChEMBLCHEMBL221722 ↗
Also known as
- 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
- avigan
- favipiravir
- favipiravir
- favipiravir
- favipiravir
- favipiravir
- favipiravir
- favipiravir
- favipiravir
- t-705
- t-705
- t-705
- t-705 cpd
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06860334 | Phase 2 | Jul 1, 2025 | University of Liverpool |
| NCT06574503 | Phase 3 | Sep 30, 2024 | Qingfeng Pharmaceutical Group |
| NCT06643156 | Phase 1 | Sep 27, 2024 | Qingfeng Pharmaceutical Group |
| NCT06678542 | Phase 1 | Sep 27, 2024 | Qingfeng Pharmaceutical Group |
| NCT06573008 | Phase 3 | Aug 31, 2024 | Qingfeng Pharmaceutical Group |
| NCT06488300 | Phase 2 | Jul 1, 2024 | University of Oxford |
| NCT06212336 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2024 | Alex Ekwueme Federal University Teaching Hospital, Alliance for International Medical Action, Bernhard Nocht Institute for Tropical Medicine, Centre de Recherche Médicale de Lambaréné, Federal Medical Centre, Owo, Government of Cote d'Ivoire, Government of France, Irrua Specialist Teaching Hospital, Medecins Sans Frontieres, University of Bordeaux, University of Hamburg, University of North Carolina at Chapel Hill |
| NCT06024421 | Phase 1 | Nov 30, 2023 | Institut National de la Santé Et de la Recherche Médicale, France, Toyama, University of Bordeaux |
| NCT05940545 | Phase 1/Phase 2 (Phase 2) | Jul 12, 2023 | University of Liverpool |
| NCT05814926 | Phase 1 | Apr 26, 2023 | Capital Medical University, Qingfeng Pharmaceutical Group |
| NCT05789342 | Phase 1 | Feb 15, 2023 | Peking University, Qingfeng Pharmaceutical Group |
| NCT05648448 | Phase 2 | Dec 22, 2022 | University of Oxford |
| NCT05474755 | Phase 3 | Jul 28, 2022 | Peking University, Qingfeng Pharmaceutical Group |
| NCT05279235 | Phase 3 | Mar 8, 2022 | Government of China, Shanghai Junshi Bioscience Co.,Ltd., Sponsor GmbH |
| NCT05218616 | Phase 1 | Jan 21, 2022 | Government of Belarus, JLLC NatiVita |
| NCT05103241 | Phase 1 | Nov 30, 2021 | Qingfeng Pharmaceutical Group |
| NCT05502081 | Phase 4 | Nov 1, 2021 | Tanta University |
| NCT04918927 | Phase 2 | Oct 12, 2021 | Government of Mexico, Hakken Enterprise, Instituto Mexicano del Seguro Social, National Polytechnic Institute, Mexico, Siegfried, Strides Pharma Science, Universidad Autonoma De Guadalajara, Mexico, University of London |
| NCT05041907 | Phase 2 | Sep 30, 2021 | University of Oxford |
| NCT05185284 | Phase 3 | Aug 11, 2021 | Moscow State Clinical Hospital №50, Promomed, LLC |
Showing 20 of 83 trials
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Organizations
Research & Development (196)
196 organizations
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