← Mechanisms of action
NS5B
SINGLE PROTEINHepatitis C virus
Preferred name: Hepatitis C virus NS5B RNA-dependent RNA polymerase ChEMBL ↗
Linked proteins
Drugs acting on this target (19)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| favipiravir | Antagonist | experimental | Small molecule | NS5B antagonist |
| balapiravir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| bms-986094 | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| dasabuvir (Exviera) | Inhibitor | approved | Small molecule | NS5B inhibitor |
| deleobuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| filibuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| mericitabine | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| nesbuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| psi-352938 | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| radalbuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| ribavirin (virazole) | Inhibitor | approved | Small molecule | NS5B inhibitor |
| setrobuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| sofosbuvir (sovaldi) | Inhibitor | approved | Small molecule | NS5B inhibitor |
| tegobuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| tmc-647055 | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| uprifosbuvir | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| valopicitabine | Inhibitor | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| beclabuvir | Negative allosteric modulator | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase negative allosteric modulator |
| lomibuvir | Negative allosteric modulator | experimental | Small molecule | Hepatitis C virus NS5B RNA-dependent RNA polymerase negative allosteric modulator |