cpi 613
Small moleculeexperimental
Clinical trial activity
7 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
5
Phase 3
1
Phase 4
0
Earliest trial started Oct 19, 2017 (NCT03435289)
Timeline
Indications
Mechanism of action
- Pyruvate dehydrogenase kinaseINHIBITOR
Pyruvate dehydrogenase kinase inhibitor
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (PDK4) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) ↗
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)CCCCC(CCSCc1ccccc1)SCc1ccccc1- Mol. weight
- 388.6 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3186849 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05854966 | Phase 2 | Feb 29, 2024 | National Cancer Institute (NCI), Rafael Pharmaceuticals Inc., Wake Forest University |
| NCT05325281 | Phase 1 | Oct 31, 2022 | Medical College of Wisconsin, Rafael Pharmaceuticals Inc. |
| NCT04203160 | Phase 1/Phase 2 (Phase 2) | Feb 29, 2020 | University of Michigan |
| NCT04217317 | Phase 2 | Feb 29, 2020 | National Cancer Institute (NCI), Wake Forest University |
| NCT03699319 | Phase 2 | Dec 4, 2018 | Case Western Reserve University |
| NCT03504423 | Phase 3 | Oct 31, 2018 | Rafael Pharmaceuticals Inc., Wayne State University |
| NCT03435289 | Phase 1 | Oct 19, 2017 | Atlantic Health System, Morristown Memorial Hospital, Rafael Pharmaceuticals Inc. |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Rafael Pharmaceuticals Inc. | For profit | 4 | 1 | 3 | 2017 |
| National Cancer Institute (NCI) | Government | 2 | 0 | 1 | 2020 |
| Wake Forest University | Academic/Hospital | 2 | 2 | 1 | 2020 |
| Atlantic Health System | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Medical College of Wisconsin | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Morristown Memorial Hospital | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Michigan | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Wayne State University | Academic/Hospital | 1 | 0 | 1 | 2018 |
9 organizations
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