ceralasertib
Small moleculeexperimental
Clinical trial activity
19 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
14
Phase 3
2
Phase 4
0
Earliest trial started Jan 31, 2018 (NCT03328273)
Timeline
Indications
Studied for
- Biliary Tract Neoplasms · Phase 1
- BRCA1 Protein · Phase 2
- Breast Neoplasms · Phase 2
- Carcinoma · Phase 1
- Carcinoma, Non-Small-Cell Lung · Phase 3
- Cholangiocarcinoma · Phase 2
- Colonic Neoplasms · Phase 1
- Colorectal Neoplasms · Phase 1
- Endometrial Neoplasms · Phase 1
- Esophageal Neoplasms · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1/Phase 2
- Lung Neoplasms · Phase 3
- Melanoma · Phase 2
- Mutation · Phase 2
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 2
- Osteosarcoma · Phase 2
- Ovarian Neoplasms · Phase 2
- Salivary Gland Neoplasms · Phase 1
- Small Cell Lung Carcinoma · Phase 2
- Stomach Neoplasms · Phase 1
- Uterine Neoplasms · Phase 1
Mechanism of action
- ATR/ATRIPINHIBITOR
ATR/ATRIP inhibitor
- Serine-protein kinase ATRINHIBITOR
Serine-protein kinase ATR inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H]1COCCN1c1cc(C2([S@](C)(=N)=O)CC2)nc(-c2cc[nH]c3nccc2-3)n1- Mol. weight
- 412.52 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4285417 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06769126 | Phase 2 | Dec 1, 2025 | National Cancer Institute (NCI), SWOG Cancer Research Network |
| NCT06929260 | Phase 1 | May 21, 2025 | AstraZeneca, Parexel |
| NCT06732401 | Phase 3 | Mar 14, 2025 | ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI) |
| NCT06680050 | Phase 2 | Jan 31, 2025 | Mario Negri Institute |
| NCT06754761 | Phase 1 | Jan 17, 2025 | AstraZeneca |
| NCT05941897 | Phase 2 | Jun 21, 2023 | AstraZeneca |
| NCT05582538 | Phase 2 | Nov 30, 2022 | AstraZeneca, IFOM |
| NCT05514132 | Phase 1 | Sep 23, 2022 | AstraZeneca, Chinese Academy of Medical Sciences |
| NCT05450692 | Phase 3 | Sep 15, 2022 | AstraZeneca, Parexel |
| NCT05469919 | Phase 1 | Jun 9, 2022 | AstraZeneca |
| NCT05061134 | Phase 2 | Jan 10, 2022 | AstraZeneca |
| NCT04699838 | Phase 2 | Apr 20, 2021 | AstraZeneca, Big Ten Cancer Research Consortium, University of Iowa |
| NCT04704661 | Phase 1 | Mar 5, 2021 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT04564027 | Phase 2 | Dec 1, 2020 | AstraZeneca |
| NCT04417062 | Phase 2 | Jul 31, 2020 | AstraZeneca, Harvard University, Osteosarcoma Institute |
| NCT04239014 | Phase 2 | Mar 24, 2020 | AstraZeneca, Parexel, University of Toronto |
| NCT04090567 | Phase 2 | Dec 5, 2019 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT03878095 | Phase 2 | Jul 1, 2019 | National Cancer Institute (NCI), Yale University |
| NCT03328273 | Phase 1/Phase 2 (Phase 2) | Jan 31, 2018 | Acerta Pharma |
Showing 19 of 19 trials
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Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AstraZeneca | For profit | 12 | 9 | 3 | 2020 |
| National Cancer Institute (NCI) | Government | 5 | 3 | 3 | 2019 |
| Parexel | For profit | 3 | 0 | 3 | 2020 |
| University of Texas at Houston | Academic/Hospital | 2 | 1 | 2 | 2019 |
| Acerta Pharma | For profit | 1 | 1 | 1 | 2018 |
| Big Ten Cancer Research Consortium | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2022 |
| ECOG-ACRIN Cancer Research Group | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| IFOM | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Mario Negri Institute | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Osteosarcoma Institute | Academic/Hospital | 1 | 0 | 1 | 2020 |
| SWOG Cancer Research Network | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Iowa | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Toronto | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Yale University | Academic/Hospital | 1 | 0 | 1 | 2019 |
16 organizations
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