imgn632
mAbexperimentalADC
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jan 4, 2018 (NCT03386513)
Timeline
2010s
- Jan 1, 2018
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Leukemia · Phase 1/Phase 2
- Leukemia, Myeloid · Phase 1
- Leukemia, Myeloid, Acute · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 1
- Myeloproliferative Disorders · Phase 1
- Plasmacytoma · Phase 1
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1/Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
Mechanism of action
- Interleukin-3 receptor subunit alphaBINDING AGENT
Interleukin-3 receptor subunit alpha binding agent
- DNADISRUPTING AGENT
DNA disrupting agent
- Interleukin-3 receptor subunit alphaINHIBITOR
IL3RA inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
- Payload
- indolinobenzodiazepine pseudodimer
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297991 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07306832 | Phase 1 | Jan 14, 2026 | AbbVie |
| NCT06034470 | Phase 1 | Jan 13, 2024 | Immunogen, University of Washington |
| NCT05320380 | Phase 1/Phase 2 (Phase 2) | Dec 20, 2022 | Immunogen, LLS PedAL Initiative, LLC, National Cancer Institute (NCI) |
| NCT04086264 | Phase 1/Phase 2 (Phase 2) | Oct 16, 2019 | Immunogen |
| NCT03386513 | Phase 1 | Jan 4, 2018 | Immunogen, Jazz Pharmaceuticals |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Immunogen | For profit | 4 | 1 | 2 | 2018 |
| AbbVie | For profit | 1 | 1 | 1 | 2026 |
| Jazz Pharmaceuticals | For profit | 1 | 0 | 1 | 2018 |
| LLS PedAL Initiative, LLC | Academic/Hospital | 1 | 1 | 1 | 2022 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2022 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2024 |
6 organizations
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