mrna-1273
Trade name: Spikevax
VaccineexperimentalCOVID-19
Clinical trial activity
95 trials · 129 clinical orgs · 0 marketing orgs
Phase 1
12
Phase 2
51
Phase 3
29
Phase 4
22
Earliest trial started Mar 19, 2020 (NCT04283461)
Timeline
Indications
Approved for
Studied for
- Anaphylaxis · Phase 3
- Arthritis · Early Phase 1
- Arthritis, Juvenile · Phase 2
- Arthritis, Psoriatic · Early Phase 1
- Arthritis, Rheumatoid · Phase 3
- Chronic Disease · Phase 2
- Coronavirus Infections · Phase 4
- COVID-19 · Phase 4
- COVID-19 Vaccines · Phase 4
- Cytomegalovirus · Phase 1
- Dermatology · Phase 2
- Dermatomyositis · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Fever · Phase 4
- Gout · Early Phase 1
- Healthy Volunteers · Phase 4
- Hematologic Neoplasms · Phase 2
- Herpes Zoster · Phase 3
- HIV · Phase 3
- HIV Infections · Phase 2/Phase 3
- Hypersensitivity · Phase 2
- Immune System Diseases · Phase 4
- Immunocompromised Host · Phase 3
- Immunoglobulin Light-chain Amyloidosis · Phase 2
- Immunosuppression Therapy · Phase 1/Phase 2
- Infections · Phase 1
- Inflammation · Early Phase 1
- Inflammatory Bowel Diseases · Phase 2
- Influenza, Human · Phase 4
- Influenza Vaccines · Phase 2
- Injection Site Reaction · Phase 4
- Kidney Diseases · Phase 4
- Kidney Transplantation · Phase 2
- Leukemia · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 3
- Live Birth · Phase 4
- Liver Transplantation · Phase 2
- Lung Transplantation · Phase 1/Phase 2
- Lupus Erythematosus, Systemic · Phase 3
- Lymphoma · Phase 2
- Lymphoma, Non-Hodgkin · Phase 3
- Mast Cell Activation Disorders · Phase 2
- Multiple Myeloma · Phase 3
- Multiple Sclerosis · Phase 4
- Neoplasms · Phase 4
- Organ Transplantation · Phase 3
- Osteoarthritis · Early Phase 1
- Pain · Phase 4
- Papillomavirus Infections · Phase 3
- Pemphigus · Phase 2
- Pneumococcal Infections · Phase 3
- Quality of Life · Phase 4
- Renal Insufficiency, Chronic · Phase 2/Phase 3
- Respiratory Syncytial Viruses · Phase 3
- Respiratory Syncytial Virus Infections · Phase 1
- Rheumatic Diseases · Phase 3
- Safety · Phase 4
- SARS-CoV-2 · Phase 4
- Sclerosis · Phase 2
- Seizures, Febrile · Phase 4
- Severe Acute Respiratory Syndrome · Phase 4
- Sjogren's Syndrome · Early Phase 1
- Spondylitis, Ankylosing · Early Phase 1
- Transplants · Phase 2
- Vaccination · Phase 2
- Vaccine-Preventable Diseases · Phase 4
- Vaccines · Phase 4
Mechanism of action
- Spike glycoproteinVACCINE ANTIGEN
Spike glycoprotein vaccine antigen
- Spike glycoproteinImmunity, active
Spike glycoprotein immunity, active
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4650491 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07279766 | Phase 4 | Dec 11, 2025 | Moderna Therapeutics, University of Copenhagen |
| NCT06599658 | Phase 2 | Nov 20, 2024 | McGill University |
| NCT06634797 | Phase 4 | Oct 8, 2024 | Moderna Therapeutics |
| NCT06633835 | Phase 4 | Sep 20, 2024 | Novavax, University of Utah |
| NCT06503900 | Phase 4 | Sep 12, 2024 | Boston University, Centers for Disease Control and Prevention (CDC), Duke University, Emory University, Wake Forest University |
| NCT06585241 | Phase 4 | Sep 9, 2024 | Moderna Therapeutics |
| NCT06354998 | Phase 3 | Apr 8, 2024 | Moderna Therapeutics |
| NCT06441955 | Phase 4 | Mar 1, 2024 | Well- Konnect Healthcare Services and Research Firm |
| NCT06038617 | Phase 4 | Oct 30, 2023 | Centers for Disease Control and Prevention (CDC), Columbia University, Duke University, Kaiser Permanente, University of Cincinnati |
| NCT06020118 | Phase 4 | Sep 25, 2023 | Arizona State University, Case Western Reserve University, Centers for Disease Control and Prevention (CDC), Duke University, University of Pittsburgh, Valleywise Health, Washington University in St. Louis |
| NCT05672355 | Phase 2 | Aug 1, 2023 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT05827926 | Phase 1/Phase 2 (Phase 2) | Apr 14, 2023 | Moderna Therapeutics |
| NCT05815498 | Phase 3 | Mar 28, 2023 | Moderna Therapeutics |
| NCT05543356 | Phase 3 | Feb 28, 2023 | Coalition for Epidemic Preparedness Innovations, Murdoch University, The Peter Doherty Institute |
| NCT05387317 | Phase 3 | Feb 28, 2023 | Coalition for Epidemic Preparedness Innovations, Government of Indonesia, Murdoch University, Padjadjaran University, The Peter Doherty Institute, University of Indonesia |
| NCT05585632 | Phase 1 | Oct 14, 2022 | Moderna Therapeutics |
| NCT05556720 | Phase 3 | Oct 1, 2022 | Monash University |
| NCT05584202 | Phase 2 | Sep 30, 2022 | Moderna Therapeutics |
| NCT05383560 | Phase 2 | Sep 5, 2022 | Moderna Therapeutics, Tel Aviv University |
| NCT05465902 | Phase 2 | Jul 31, 2022 | Government of China |
Showing 20 of 95 trials
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Organizations
Research & Development (129)
129 organizations
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