hydrogen peroxide
Small moleculeexperimental
Hydrogen peroxide–urea is a white crystalline solid chemical compound composed of equimolar amounts of hydrogen peroxide and urea. It contains solid and water-free hydrogen peroxide, which offers a higher stability and better controllability than liquid hydrogen peroxide when used as an oxidizing agent. Often called carbamide peroxide in dentistry, it is used as a source of hydrogen peroxide when dissolved in water for bleaching, disinfection and oxidation. — Wikipedia
Clinical trial activity
87 trials · 80 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
30
Phase 3
14
Phase 4
12
Earliest trial started Mar 31, 2008 (NCT01732744)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 3
- Basal Cell Carcinoma · Phase 2
- Breast Neoplasms · Phase 2
- Carcinoma, Squamous Cell · Phase 2
- Chronic Periodontitis · Phase 4
- Coronavirus · Phase 4
- Coronavirus Infections · Phase 2
- COVID-19 · Phase 4
- Dental Caries · Early Phase 1
- Dental Implantation · Early Phase 1
- Dentin Sensitivity · Phase 4
- Dermatitis, Seborrheic · Phase 1/Phase 2
- Dermatology · Phase 2
- Diabetes Mellitus · Early Phase 1
- Gingivitis · Phase 3
- Healthy Volunteers · Phase 2
- Hemorrhage · Phase 3
- Inflammation · Phase 1
- Keratosis, Seborrheic · Phase 4
- Mouth Diseases · Phase 3
- Mouthwashes · Phase 4
- Mucositis · Early Phase 1
- Osteoarthritis · Phase 4
- Peri-Implantitis · Early Phase 1
- Periodontal Attachment Loss · Phase 1
- Periodontal Diseases · Phase 3
- Periodontal Pocket · Phase 3
- Periodontitis · Phase 3
- Polymerase Chain Reaction · Phase 4
- Prostheses and Implants · Early Phase 1
- Saliva · Phase 4
- SARS-CoV-2 · Phase 4
- Tooth Abnormalities · Phase 4
- Tooth Bleaching · Phase 4
- Tooth Discoloration · Phase 4
- Uterine Cervical Neoplasms · Phase 1
- Ventilators, Mechanical · Phase 4
- Viral Load · Phase 4
- Warts · Phase 3
- Wound Healing · Phase 3
Mechanism of action
- free radicalRELEASING AGENT
free radical releasing agent
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaHydrogen peroxide–urea ↗
- WikipediaHydrogen peroxide - urea ↗
- WikipediaHydrogen peroxide ↗
- WikipediaA101 ↗
Also known as
- a 101
- a-101
- a-101
- a-101
- carbamide peroxide
- carbamide peroxide
- carbamide peroxide
- carbamide peroxide
- carbamide peroxide
- carbamide peroxide
- cd1579
- dl-phenylalanine, 4-nitro-n-(((phenylacetyl)amino)methyl)-
- glycerite of hydrogen peroxide
- n-phenylacetoaminomethylene-dl-p-nitrophenylalanine
- perhydrol urea
- peroxide carbamide
- urea, compd. with hydrogen peroxide (h2o2) (1:1)
- urea, cpd with hydrogen peroxide (1:1)
- urea hydrogen peroxide
- urea hydrogen peroxide
- urea peroxide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07233837 | N/A | Nov 17, 2025 | Albert Einstein Israelite Hospital, Beneficência Portuguesa de Sao Paulo, Hospital do Coracao |
| NCT07144527 | N/A | Sep 15, 2025 | Concordia University |
| NCT07031388 | N/A | Jul 1, 2025 | Kurdistan Board for Medical Specialist |
| NCT06884813 | N/A | Mar 10, 2025 | King Abdullah Medical City |
| NCT06518629 | N/A | Jul 15, 2024 | Universidade Federal do Para |
| NCT07287956 | N/A | Feb 5, 2024 | Jordan University, King Abdullah Medical City |
| NCT06606236 | N/A | Feb 5, 2024 | Institucion Universitaria Colegios de Colombia |
| NCT06855940 | N/A | Feb 2, 2024 | Erciyes University |
| NCT06949176 | N/A | Dec 1, 2023 | University of Athens |
| NCT06045429 | Phase 4 | Sep 30, 2023 | Charles University |
| NCT06904118 | N/A | Jun 13, 2023 | Government of Pakistan |
| NCT06404190 | Phase 1 | May 28, 2023 | Krishnadevaraya College of Dental Sciences & Hospital |
| NCT05787600 | Phase 3 | Mar 3, 2023 | University of Baghdad |
| NCT05669560 | Early Phase 1 (Phase 1) | Jan 20, 2023 | University of Oklahoma |
| NCT05570422 | Phase 1 | Jan 1, 2023 | Kortuc Inc. |
| NCT05605834 | N/A | Dec 31, 2022 | Cairo University |
| NCT06812065 | N/A | Dec 7, 2022 | China Medical University |
| NCT05198180 | Phase 3 | Feb 28, 2022 | Sohag University |
| NCT05635253 | N/A | Jan 10, 2022 | Universidade Federal do Para |
| NCT05024760 | Early Phase 1 (Phase 1) | Nov 30, 2021 | United States Army |
Showing 20 of 87 trials
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Organizations
Research & Development (80)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aclaris Therapeutics, Inc. | For profit | 15 | 15 | 3 | 2013 |
| Universidade Federal do Para | Academic/Hospital | 5 | 5 | 1 | 2016 |
| Galderma | For profit | 4 | 4 | 2 | 2013 |
| University of Chile | Academic/Hospital | 4 | 4 | 2 | 2013 |
| Colgate Palmolive | For profit | 3 | 2 | 2 | 2020 |
| Loma Linda University | Academic/Hospital | 3 | 1 | 2 | 2018 |
| Universidade Federal de Sergipe | Academic/Hospital | 3 | 3 | 3 | 2014 |
| University of Milan | Academic/Hospital | 3 | 3 | 1 | 2020 |
| Albert Einstein Israelite Hospital | Academic/Hospital | 2 | 2 | 1 | 2020 |
| BMG PHARMA | For profit | 2 | 0 | 1 | 2020 |
| Derm Research Incorporated | For profit | 2 | 0 | 1 | 2013 |
| Fundação de Amparo à Pesquisa do Estado de São Paulo | Academic/Hospital | 2 | 0 | 2 | 2008 |
| GlaxoSmithKline | For profit | 2 | 1 | 1 | 2011 |
| King Abdullah Medical City | Academic/Hospital | 2 | 2 | 1 | 2024 |
| Kortuc Inc. | For profit | 2 | 1 | 2 | 2019 |
| University of London | Academic/Hospital | 2 | 2 | 2 | 2019 |
| University of Nove de Julho | Academic/Hospital | 2 | 2 | 1 | 2013 |
| University of Sao Paulo | Academic/Hospital | 2 | 1 | 1 | 2008 |
| A.T. Still University of Health Sciences | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Augusta University | Academic/Hospital | 1 | 1 | 1 | 2020 |
80 organizations
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