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tetracycline

Trade name: tetrex

Small moleculeapproved

Approved

Nov 19, 1953

Tetracycline, sold under various brand names, is an antibiotic in the tetracyclines family of medications, used to treat a number of infections, including acne, cholera, brucellosis, plague, malaria, and syphilis. It is available in oral and topical formulations. — Wikipedia

Clinical trial activity

116 trials · 147 clinical orgs · 44 marketing orgs

Phase 1
6
Phase 2
27
Phase 3
16
Phase 4
54

Earliest trial started Oct 1, 1992 (NCT00591162)

Timeline

1950s

  1. Nov 19, 1953

    Earliest FDA Approval

  2. Nov 19, 1953

    Lederle — NDA Secondary Org

  3. Nov 19, 1953

    American Cyanamid — NDA Secondary Org

  4. Jan 4, 1954

    Pfizer — Marketing Organization

  5. Sep 17, 1954

    Apothecon — Marketing Organization

  6. Sep 28, 1954

    Pharmacia & Upjohn — Marketing Organization

  7. Nov 23, 1955

    Karl Storz — NDA Secondary Org

  8. Feb 19, 1957

    Bristol-Myers — First NDA Organization

  9. Feb 19, 1957

    Bristol-Myers — NDA Organization

  10. Jun 21, 1957

    Par Pharmaceuticals — Marketing Organization

  11. Oct 8, 1957

    Heritage Pharma — NDA Secondary Org

  12. Oct 8, 1957

    Heritage Pharma — Marketing Organization

1960s

  1. Jul 5, 1963

    Teva — Marketing Organization

  2. Oct 22, 1964

    John J. Ferrante — Marketing Organization

  3. Jul 17, 1968

    Mylan — Marketing Organization

  4. Jul 17, 1968

    Aurobindo Pharma — Marketing Organization

1970s

  1. Jul 13, 1971

    Impax Laboratories — Marketing Organization

  2. May 22, 1972

    Roxane Laboratories — Marketing Organization

  3. Jun 20, 1972

    Bristol-Myers — Marketing Organization

  4. Jun 8, 1973

    Warner Chilcott — Marketing Organization

  5. Dec 24, 1974

    Watson Pharmaceuticals — Marketing Organization

  6. Sep 2, 1977

    MM Pharma — Marketing Organization

  7. Sep 21, 1977

    Shire — NDA Secondary Org

  8. Nov 7, 1977

    Hikma — Marketing Organization

1980s

  1. Feb 7, 1980

    Sun Pharmaceuticals — Marketing Organization

  2. Mar 21, 1985

    Superpharm — Marketing Organization

  3. Aug 12, 1988

    Chartwell Pharmaceuticals — Marketing Organization

  4. Sep 6, 1988

    Ani Pharmaceuticals — Marketing Organization

1990s

  1. Jan 1, 1992

    Earliest Phase 2 Sponsor(trial)

  2. Mar 25, 1994

    Schiff Nutrition — NDA Secondary Org

  3. Aug 15, 1996

    Casper Pharma LLC — Marketing Organization

  4. Aug 15, 1996

    Casper Pharma LLC — NDA Secondary Org

  5. Jan 1, 1999

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Sep 28, 2006

    Allergan — NDA Secondary Org

  2. Sep 28, 2006

    AbbVie — NDA Secondary Org

2010s

  1. Jan 1, 2011

    Earliest Phase 1 Sponsor(trial)

  2. Sep 18, 2018

    Amneal Pharmaceuticals — Marketing Organization

  3. Nov 7, 2018

    Esteve Labs — Marketing Organization

  4. Nov 30, 2018

    Ailex Pharmaceuticals — Marketing Organization

2020s

  1. Mar 3, 2020

    Strides Pharma Science — Marketing Organization

  2. Mar 6, 2023

    Bristol-Myers Squibb — Marketing Organization

  3. Jul 3, 2023

    RiconPharma — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedNov 19, 1953

Chemistry & pharmacology

Loading structure…

SMILES

[Ca++].CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1[O-].CN(C)[C@H]5[C@@H]6C[C@H]7C(C(=O)C8=C(O)C=CC=C8[C@@]7(C)O)=C(O)[C@]6(O)C(=O)C(C(N)=O)=C5[O-]
Mol. weight
926.931 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Discontinued

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • (4s,4as,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • (4s,4as,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • abramycin
  • abramycin
  • achromycin
  • achromycin
  • achromycin
  • achromycin v
  • achromycin v
  • actisite
  • actisite
  • bristacycline
  • bristacycline
  • ciclolysine
  • cyclopar
  • cyclopar
  • deschlorobiomycin
  • deschlorobiomycin
  • e701
  • e701
  • economycin
  • latycin
  • limeciclina
  • limeciclina
  • liquamycin
  • liquamycin
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecycline
  • lymecyclinum
  • lymecyclinum
  • mrc375
  • mucomycin
  • n2-(((+)-5-amino-5-carboxypentylamino)methyl)tetracycline
  • n2-(((+)-5-amino-5-carboxypentylamino)methyl)tetracycline
  • (+)-n-(5-amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
  • (+)-n-(5-amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
  • n6-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido)methyl)lysine
  • n6-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido)methyl)lysine
  • n-lysinomethyltetracycline
  • n-lysinomethyltetracycline
  • panmycin
  • panmycin
  • retet
  • retet
  • robitet
  • robitet
  • sumycin
  • sumycin
  • supramycin
  • supramycin
  • sustamycin
  • sustamycin
  • tetrabid organon
  • tetrachel
  • tetrachel
  • tetracyclin
  • tetracyclin
  • tetracycline
  • tetracycline
  • tetracycline
  • tetracycline
  • tetracycline
  • tetracycline
  • tetracycline
  • tetracycline
  • tétracycline
  • tétracycline
  • tetracycline hcl
  • tetracycline hcl
  • tetracycline hcl
  • tetracycline hydrochloride
  • tetracycline hydrochloride
  • tetracycline hydrochloride
  • tetracycline hydrochloride
  • tetracycline hydrochloride
  • tetracycline-l-methylenelysine
  • tetracycline-l-methylenelysine
  • tetracycline-l-methylenelysine
  • tetracycline-l-methylene lysine
  • tetracycline-l-methylene lysine
  • tetracycline metaphosphate
  • tetracycline metaphosphate
  • tetracycline metaphosphate
  • tetracyclinemethylenelysine
  • tetracycline metronidazole
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracycline phosphate complex
  • tetracyclinum
  • tetracyclinum
  • tetracyline
  • tetracyn
  • tetracyn
  • tetralysal 150
  • tetralysal 300
  • tetramed
  • tetramed
  • tetrazyklin
  • tetrazyklin
  • tetrex
  • tetrex
  • tetrex
  • topicycline
  • topicycline
  • tsiklomitsin
  • tsiklomitsin
  • vetquamycin
  • vetquamycin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07139366Phase 4Sep 30, 2025People's Liberation Army of China
NCT07144657Phase 2Sep 1, 2025National Taiwan University
NCT06977841N/AJun 10, 2025Fudan University
NCT06955104Phase 3Apr 3, 2025JW Pharmaceutical
NCT07068607Phase 4Apr 1, 2025People's Liberation Army of China
NCT06225570Early Phase 1 (Phase 1)Jan 31, 2025Medical University of South Carolina
NCT06723197Phase 4Dec 10, 2024Feicheng Municipal People's Hospital, Qilu Hospital of Shandong University, Shandong University, The People's Hospital of Jimo.Qingdao, Zaozhuang Municipal Hospital, Zibo Maternal and Child Health Hospital
NCT06299605N/ANov 27, 2024Feicheng Municipal People's Hospital, Shandong University, Zaozhuang Municipal Hospital, Zibo Maternal and Child Health Hospital
NCT06561711Phase 4Aug 21, 2024Jiao Tong University
NCT06509139Phase 4Jul 9, 2024National Cheng Kung University
NCT06351891Phase 4Apr 30, 2024Shandong University
NCT06759610N/AFeb 10, 2024Minia University
NCT06168214Phase 4Sep 4, 2023People's Liberation Army of China
NCT05874570Phase 4Jun 20, 2023Jiao Tong University
NCT06168084Phase 4Jun 6, 2023People's Liberation Army of China
NCT05874544Phase 4May 16, 2023Jiao Tong University
NCT05802888Phase 4Mar 12, 2023Central Hospital, Zibo, Peking University, Shandong University, Taierzhuang District People's Hospital, Zhengzhou University
NCT05219929Phase 2Nov 2, 2022Johns Hopkins University
NCT05431075Phase 4Jul 31, 2022Central Hospital, Zibo, Peking University, Shandong University, Taierzhuang District People's Hospital, Yuncheng Hospital of Traditional Chinese Medicine, Zhengzhou University
NCT05432115Phase 4Jun 15, 2022Central Hospital, Zibo, Peking University, Shandong University, Taierzhuang District People's Hospital, Yuncheng Hospital of Traditional Chinese Medicine, Zhengzhou University
Showing 20 of 116 trials
Page 1 / 6

Organizations

Research & Development (147)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Shandong UniversityAcademic/Hospital171722017
Jiao Tong UniversityAcademic/Hospital9912012
People's Liberation Army of ChinaGovernment9722016
National Taiwan UniversityAcademic/Hospital6632015
Seoul National UniversityAcademic/Hospital6532003
Kaohsiung Medical UniversityAcademic/Hospital5222013
Peking UniversityAcademic/Hospital5222021
Taichung Veterans General HospitalAcademic/Hospital5512013
Fudan UniversityAcademic/Hospital4422021
Central Hospital, ZiboAcademic/Hospital3012022
Taierzhuang District People's HospitalAcademic/Hospital3012022
Technion UniversityAcademic/Hospital3122006
University of Texas at HoustonAcademic/Hospital3321995
Zhengzhou UniversityAcademic/Hospital3012022
CJ HealthCare Corp.For profit2122014
Feicheng Municipal People's HospitalAcademic/Hospital2022024
Government of MexicoGovernment2222010
Hallym UniversityAcademic/Hospital2122014
Heze Municipal 3rd people's hospitalAcademic/Hospital2012021
International Agency for Research on CancerAcademic/Hospital2122014
147 organizations
Page 1 / 8

Marketing (51)

OrganizationOrg typeRelationshipDate
ANGUSFor profitMKTG—
AbbVieFor profitNDA2Sep 28, 2006
AbbottFor profitMKTG—
Ailex PharmaceuticalsFor profitMKTGNov 30, 2018
AllerganFor profitNDA2Sep 28, 2006
AlpharmaFor profitMKTG—
American CyanamidFor profitNDA2Nov 19, 1953
American Home ProductsFor profitMKTG—
Amneal PharmaceuticalsFor profitMKTGSep 18, 2018
Ani PharmaceuticalsFor profitSYNSep 6, 1988
Ani PharmaceuticalsFor profitMKTGSep 6, 1988
ApotheconFor profitMKTGSep 17, 1954
Aurobindo PharmaFor profitMKTGJul 17, 1968
Bausch Health CompaniesFor profitMKTG—
Bristol-MyersFor profitNDAFeb 19, 1957
Bristol-MyersFor profitMKTGJun 20, 1972
Bristol-Myers SquibbFor profitMKTGMar 6, 2023
Casper Pharma LLCFor profitMKTGAug 15, 1996
Casper Pharma LLCFor profitNDA2Aug 15, 1996
Chartwell PharmaceuticalsFor profitMKTGAug 12, 1988
Elkins SinnFor profitMKTG—
Esteve LabsFor profitSYNNov 7, 2018
Esteve LabsFor profitMKTGNov 7, 2018
Heather PharmaFor profitMKTG—
Heritage PharmaFor profitNDA2Oct 8, 1957
Heritage PharmaFor profitMKTGOct 8, 1957
HikmaFor profitMKTGNov 7, 1977
HikmaFor profitSYNNov 7, 1977
Impax LaboratoriesFor profitMKTGJul 13, 1971
John J. FerranteFor profitMKTGOct 22, 1964
Karl StorzFor profitNDA2Nov 23, 1955
LederleFor profitNDA2Nov 19, 1953
MM PharmaFor profitMKTGSep 2, 1977
MylanFor profitMKTGJul 17, 1968
Par PharmaceuticalsFor profitMKTGJun 21, 1957
PfizerFor profitSYNSep 2, 1955
PfizerFor profitMKTGJan 4, 1954
Pharmacia & UpjohnFor profitMKTGSep 28, 1954
ProterFor profitMKTG—
Puracap PharmaceuticalFor profitMKTG—
RiconPharmaFor profitMKTGJul 3, 2023
Roxane LaboratoriesFor profitMKTGMay 22, 1972
Schiff NutritionFor profitNDA2Mar 25, 1994
ShireFor profitNDA2Sep 21, 1977
SolvayFor profitMKTG—
Strides Pharma ScienceFor profitMKTGMar 3, 2020
Sun PharmaceuticalsFor profitMKTGFeb 7, 1980
SuperpharmFor profitMKTGMar 21, 1985
TevaFor profitMKTGJul 5, 1963
Warner ChilcottFor profitMKTGJun 8, 1973
Watson PharmaceuticalsFor profitMKTGDec 24, 1974