CDEK
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rigosertib

Small moleculeexperimental

Rigosertib is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics. Rigosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia. — Wikipedia

Clinical trial activity

38 trials · 23 clinical orgs · 0 marketing orgs

Phase 1
26
Phase 2
17
Phase 3
4
Phase 4
0

Earliest trial started Jun 1, 2006 (NCT01538563)

Timeline

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(NCC(=O)O)c2)c(OC)c1
Mol. weight
451.5 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • (n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetic acid
  • n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide
  • on01910
  • on 01910
  • on 01910
  • on 01910
  • on-01910
  • on-01910
  • on-01910
  • on 01910.na
  • on 01910.na
  • on 01910.na
  • on-01910.na
  • on-01910.na
  • rigosertib
  • rigosertib
  • rigosertib
  • rigosertib
  • rigosertib
  • rigosertib sodium
  • rigosertib sodium
  • rigosertib sodium
  • sodium (n-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05764395Phase 2May 9, 2023Vanderbilt University
NCT04263090Phase 1/Phase 2 (Phase 2)Feb 29, 2020Bristol-Myers Squibb, Icahn School of Medicine at Mount Sinai, Onconova Therapeutics, Inc., Traws Pharma, Inc.
NCT04177498Early Phase 1 (Phase 1)Dec 31, 2019Onconova Therapeutics, Inc., Thomas Jefferson University
NCT03786237Phase 1/Phase 2 (Phase 2)May 31, 2019Paracelsus Medical University, University of Salzburg
NCT03495167Phase 1Oct 6, 2017SymBio Pharmaceuticals
NCT02730884Phase 2Dec 1, 2016Onconova Therapeutics, Inc., University of Texas at Houston
NCT02783547Phase 1Dec 1, 2015SymBio Pharmaceuticals
NCT02562443Phase 3Oct 1, 2015Onconova Therapeutics, Inc.
NCT02000154Phase 1Dec 1, 2014SymBio Pharmaceuticals
NCT02075034Phase 1May 1, 2014Columbia University, Onconova Therapeutics, Inc.
NCT02107235Phase 1Jan 1, 2014Onconova Therapeutics, Inc., University of Colorado, Denver
NCT02030639Phase 1Jan 1, 2014Onconova Therapeutics, Inc.
NCT01926587Phase 2Aug 1, 2013Onconova Therapeutics, Inc.
NCT02002936Phase 1Aug 1, 2013SymBio Pharmaceuticals
NCT01928537Phase 3Aug 1, 2013Onconova Therapeutics, Inc.
NCT01904682Phase 2Jul 1, 2013Onconova Therapeutics, Inc.
NCT02014051Phase 1Mar 1, 2013SymBio Pharmaceuticals
NCT01807546Phase 2Mar 1, 2013Onconova Therapeutics, Inc.
NCT01700335Phase 1Jun 1, 2012SymBio Pharmaceuticals
NCT01584531Phase 2May 1, 2012Onconova Therapeutics, Inc.
Showing 20 of 38 trials
Page 1 / 2

Organizations

Research & Development (23)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Onconova Therapeutics, Inc.For profit282532006
SymBio PharmaceuticalsFor profit6612012
Columbia UniversityAcademic/Hospital4022009
Icahn School of Medicine at Mount SinaiAcademic/Hospital4122006
Yeshiva UniversityAcademic/Hospital3012006
National Heart, Lung, and Blood Institute (NHLBI)Government2212007
University of ColoradoAcademic/Hospital2012009
University of Texas at HoustonAcademic/Hospital2112010
Academic Oncology Gastrointestinal Cancer ConsortiumAcademic/Hospital1012011
Anschutz Cancer PavilionAcademic/Hospital1012011
Bristol-Myers SquibbFor profit1012020
Cornell UniversityAcademic/Hospital1012009
National Cancer Institute (NCI)Government1012009
Paracelsus Medical UniversityAcademic/Hospital1012019
Stanford UniversityAcademic/Hospital1012009
The Leukemia and Lymphoma SocietyAcademic/Hospital1012010
Thomas Jefferson UniversityAcademic/Hospital1112019
Traws Pharma, Inc.For profit1012020
University of California, San FranciscoAcademic/Hospital1012010
University of Colorado, DenverAcademic/Hospital1012014
23 organizations
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