isopropamide iodide
Trade name: darbid
Small moleculeapproved
Approved
Oct 9, 1957
Isopropamide is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1950s
- Oct 9, 1957
GlaxoSmithKline — Earliest FDA Approval
- Oct 9, 1957
GlaxoSmithKline — NDA Secondary Org
- Oct 9, 1957
GlaxoSmithKline — NDA Organization
Indications
Mechanism of action
- Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Role in regulating gastric secretion, M1 likely involved
- Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Role in regulating gastric secretion, M3 likely involved
Approval history
- approvedOct 9, 1957
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C- Mol. weight
- 353.53 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1201232 ↗
- WikipediaIsopropamide ↗
- NCATS8B9I31H724 ↗
- ChEMBLCHEMBL1200347 ↗
Also known as
- benzenepropanaminium, gamma-(aminocarbonyl)-n-methyl-n,n-bis(1-methylethyl)-gamma-phenyl-, iodide
- bispan
- darbid
- darbid
- darbid
- isopropamid
- isopropamide
- isopropamide
- isopropamide
- isopropamide
- isopropamide
- isopropamide
- isopropamide
- isopropamide
- isopropamide bromide
- isopropamide bromide
- isopropamide bromide
- isopropamide bromide
- isopropamide bromide
- isopropamide iodide
- isopropamide iodide
- isopropamide iodide
- isopropamide iodide
- isopropamide iodide
- isoproponum iodide
- isoproponum iodide
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| GlaxoSmithKline | For profit | NDA2 | Oct 9, 1957 |
| GlaxoSmithKline | For profit | NDA | Oct 9, 1957 |