dinoprost tromethamine

Trade name: prostin f2 alpha

Small moleculeapproved

Approved

Dec 4, 1975

Prostaglandin F2α, pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. Prostaglandins are lipids throughout the entire body that have a hormone-like function. In pregnancy, PGF2α is medically used to sustain contracture and provoke myometrial ischemia to accelerate labor and prevent significant blood loss in labor. Additionally, PGF2α has been linked to being naturally involved in the process of labor. It has been seen that there are higher levels of PGF2α in maternal fluid during labor when compared to at term. This signifies that there is likely a biological use and significance to the production and secretion of PGF2α in labor. Prostaglandin is also used to treat uterine infections in domestic animals. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1970s

  1. Dec 4, 1975

    Pharmacia & Upjohn — Earliest FDA Approval

  2. Dec 4, 1975

    Pharmacia & Upjohn — NDA Secondary Org

  3. Dec 4, 1975

    Pharmacia & Upjohn — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedDec 4, 1975

Chemistry & pharmacology

Loading structure…

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O.NC(CO)(CO)CO
Mol. weight
475.62 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Discontinued

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • dinoprost tromethamine
  • dinoprost tromethamine
  • dinoprost tromethamine
  • dinoprost tromethamine
  • dinoprost tromethamine
  • dinoprost tromethamine
  • lutalyse
  • lutalyse
  • lutalyse
  • minprostin f2 alpha
  • pgf2a
  • pgf2a
  • pgf2alpha tromethamine
  • pharmacia brand of dinoprost tromethamine
  • prostaglandin f2alpha tromethamine
  • prostin f2
  • prostin f2 alpha
  • prostin f2 alpha
  • prostin f2 alpha

Organizations

Marketing (2)

OrganizationOrg typeRelationshipDate
Pharmacia & UpjohnFor profitNDA2Dec 4, 1975
Pharmacia & UpjohnFor profitNDADec 4, 1975