dinoprost tromethamine
Trade name: prostin f2 alpha
Approved
Dec 4, 1975
Prostaglandin F2α, pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. Prostaglandins are lipids throughout the entire body that have a hormone-like function. In pregnancy, PGF2α is medically used to sustain contracture and provoke myometrial ischemia to accelerate labor and prevent significant blood loss in labor. Additionally, PGF2α has been linked to being naturally involved in the process of labor. It has been seen that there are higher levels of PGF2α in maternal fluid during labor when compared to at term. This signifies that there is likely a biological use and significance to the production and secretion of PGF2α in labor. Prostaglandin is also used to treat uterine infections in domestic animals. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Timeline
1970s
- Dec 4, 1975
Pharmacia & Upjohn — Earliest FDA Approval
- Dec 4, 1975
Pharmacia & Upjohn — NDA Secondary Org
- Dec 4, 1975
Pharmacia & Upjohn — NDA Organization
Indications
Approved for
Mechanism of action
Approval history
- approvedDec 4, 1975
Chemistry & pharmacology
SMILES
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O.NC(CO)(CO)CO- Mol. weight
- 475.62 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaProstaglandin F2alpha ↗
- ChEMBLCHEMBL1200896 ↗
Also known as
- dinoprost tromethamine
- dinoprost tromethamine
- dinoprost tromethamine
- dinoprost tromethamine
- dinoprost tromethamine
- dinoprost tromethamine
- lutalyse
- lutalyse
- lutalyse
- minprostin f2 alpha
- pgf2a
- pgf2a
- pgf2alpha tromethamine
- pharmacia brand of dinoprost tromethamine
- prostaglandin f2alpha tromethamine
- prostin f2
- prostin f2 alpha
- prostin f2 alpha
- prostin f2 alpha
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Pharmacia & Upjohn | For profit | NDA2 | Dec 4, 1975 |
| Pharmacia & Upjohn | For profit | NDA | Dec 4, 1975 |