entumine
Clotiapine (Entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries, Argentina, Taiwan and Israel in 1970. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Mechanism of action
- Dopamine D4 receptorANTAGONIST
DRD4 antagonist
Clotiapine affects multiple receptors. It blocks 5HT3-receptors and downregulates cortical 5HT2- receptors. It has high affinity for the 5HT-6 and 5HT-7 receptors and acts as an antagonist of the D-4 receptors.
- Serotonin 2 (5-HT2) receptorANTAGONIST
Serotonin 2 (5-HT2) receptor antagonist
Clotiapine affects multiple receptors. It blocks 5HT3-receptors and downregulates cortical 5HT2- receptors. It has high affinity for the 5HT-6 and 5HT-7 receptors and acts as an antagonist of the D-4 receptors.
- Serotonin 3 (5-HT3) receptorANTAGONIST
Serotonin 3 (5-HT3) receptor antagonist
Clotiapine affects multiple receptors. It blocks 5HT3-receptors and downregulates cortical 5HT2- receptors. It has high affinity for the 5HT-6 and 5HT-7 receptors and acts as an antagonist of the D-4 receptors.
Chemistry & pharmacology
SMILES
CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1- Mol. weight
- 343.88 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaClotiapine ↗
- ChEMBLCHEMBL304902 ↗
Also known as
- clothiapin
- clothiapine
- clothiapine
- clothiapine
- clothiapine
- clothiapine
- clotiapine
- clotiapine
- clotiapine
- clotiapine
- clotiapine
- dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
- entumine
- entumine
- hf-2159
- hf-2159