chtnt-1
mAbexperimental
Clinical trial activity
5 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2000 (NCT00004017)
Timeline
Indications
Mechanism of action
- DNA-histone H1 complexBINDING AGENT
DNA-histone H1 complex binding agent
- Histone H1.1INHIBITOR
H1-1 inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
- Payload
- 131-iodine
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2109644 ↗
- ChEMBLCHEMBL2109386 ↗
Also known as
- 131i-chimeric tnt-1-b monoclonal antibody
- 131i-chtnt-1/b
- 131-i-chtnt-1/b mab
- 131i-chtnt-1-b mab
- 131i-chtnt-1-b monoclonal antibody
- chtnt-1
- chtnt-1 131i
- cotara
- cotara
- cotara
- tnt-1b
- tnt-1/b
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02724267 | N/A | Nov 1, 2012 | Eastern Hepatobiliary Surgery Hospital |
| NCT00677716 | Phase 2 | Jul 1, 2007 | All India Institute of Medical Sciences, Avid Bioservices |
| NCT00509301 | Phase 1 | Nov 1, 2006 | Avid Bioservices, Barrow Neurological Institute, Case Western Reserve University, Medical University of South Carolina, University of Pennsylvania |
| NCT00128635 | Phase 1 | Oct 1, 2005 | National Cancer Institute (NCI), University of Pennsylvania |
| NCT00004017 | Phase 2 | Feb 1, 2000 | Avid Bioservices |
Showing 5 of 5 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Avid Bioservices | For profit | 3 | 3 | 2 | 2000 |
| University of Pennsylvania | Academic/Hospital | 2 | 1 | 1 | 2005 |
| All India Institute of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Barrow Neurological Institute | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Case Western Reserve University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Eastern Hepatobiliary Surgery Hospital | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Medical University of South Carolina | Academic/Hospital | 1 | 0 | 1 | 2006 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2005 |
8 organizations
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