broxuridine
Small moleculeexperimental
Bromodeoxyuridine is a synthetic nucleoside analogue with a chemical structure similar to thymidine. BrdU is commonly used to study cell proliferation in living tissues and has been studied as a radiosensitizer and diagnostic tool in people with cancer. — Wikipedia
Clinical trial activity
2 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 1998 (NCT00003405)
Timeline
1990s
- Jan 1, 1998
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
Mechanism of action
- DNAINHIBITOR
DNA inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1Br- Mol. weight
- 307.1 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBromodeoxyuridine ↗
- ChEMBLCHEMBL222280 ↗
Also known as
- 5-bromodeoxyuridine
- bromodeoxyuridine
- bromodeoxyuridine
- bromodeoxyuridine
- bromodeoxyuridine
- broxuridine
- broxuridine
- broxuridine
- broxuridine
- broxuridine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00003832 | Phase 2 | Jul 1, 1999 | National Cancer Institute (NCI), University of Colorado, Denver |
| NCT00003405 | Phase 2 | Apr 1, 1998 | National Cancer Institute (NCI), Rush University |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 2 | 1 | 1 | 1998 |
| Rush University | Academic/Hospital | 1 | 1 | 1 | 1998 |
| University of Colorado, Denver | Academic/Hospital | 1 | 0 | 1 | 1999 |
3 organizations
Page 1 / 1