tolmetin
Trade name: tolectin
Approved
Mar 24, 1976
Tolmetin is a nonsteroidal anti-inflammatory agent. It was marketed as Tolectin in USA. TOLECTIN (tolmetin sodium) is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. TOLECTIN is indicated in the treatment of acute flares and the long-term management of the chronic disease. TOLECTIN is also indicated for treatment of juvenile rheumatoid arthritis. The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 14 marketing orgs
Timeline
1970s
- Mar 24, 1976
Johnson and Johnson — Earliest FDA Approval
- Mar 24, 1976
Johnson and Johnson — NDA Secondary Org
- Mar 24, 1976
Johnson and Johnson — NDA Organization
1990s
- Nov 27, 1991
Sun Pharmaceuticals — Marketing Organization
- Nov 27, 1991
ANDA Repository — Marketing Organization
- Nov 27, 1991
Senores Pharms — Marketing Organization
- Jan 24, 1992
Actavis — Marketing Organization
- Jan 24, 1992
Teva — Marketing Organization
- Jan 24, 1992
Ani Pharmaceuticals — Marketing Organization
- Apr 30, 1992
Fosun — Marketing Organization
- Apr 30, 1992
Chartwell Pharmaceuticals — Marketing Organization
- May 27, 1993
Mylan — Marketing Organization
- May 27, 1993
Rising Pharmaceuticals — Marketing Organization
- Mar 28, 1996
Cosette — Marketing Organization
- Mar 28, 1996
G & W Laboratories Inc. — Marketing Organization
- Mar 28, 1996
ACP Nimble — Marketing Organization
Indications
Studied for
Mechanism of action
- CyclooxygenaseINHIBITOR
Cyclooxygenase inhibitor
Approval history
- approvedMar 24, 1976
Chemistry & pharmacology
SMILES
Cc1ccc(C(=O)c2ccc(CC(=O)O)n2C)cc1- Mol. weight
- 257.29 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1020 ↗
- WikipediaTolmetin ↗
- NCATSD8K2JPN18B ↗
- ChEMBLCHEMBL1766570 ↗
- ChEMBLCHEMBL1200613 ↗
Also known as
- 1-methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid
- 1-methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid
- 1-methyl-5-p-toluoylpyrrole-2-acetic acid
- 1-methyl-5-p-toluoylpyrrole-2-acetic acid
- 5-(p-toluoyl)-1-methylpyrrole-2-acetic acid
- 5-(p-toluoyl)-1-methylpyrrole-2-acetic acid
- amtolmetineguacil
- amtolmetineguacil
- amtolmetineguacil
- amtolmetineguacil
- amtolmetin guacil
- amtolmetin guacil
- amtolmetin guacil
- amtolmetin guacil
- amtolmetin guacyl
- artromed
- mcn-2559
- mcn-2559
- mcn-2559-21-98
- mcn-2559-21-98
- st-679
- tolectin
- tolectin
- tolectin
- tolectin 600
- tolectin 600
- tolectin ds
- tolectin ds
- tolmetin
- tolmetin
- tolmetin
- tolmetin
- tolmetin
- tolmetin
- tolmetin
- tolmetina
- tolmetina
- tolmetine
- tolmétine
- tolmétine
- tolmetino
- tolmetino
- tolmetin sodium
- tolmetin sodium
- tolmetin sodium
- tolmetin sodium
- tolmetin sodium anhydrous
- tolmetin sodium anhydrous
- tolmetin sodium anhydrous
- tolmetin sodium anhydrous
- tolmetin sodium anhydrous
- tolmetin sodium anhydrous
- tolmetin sodium salt
- tolmetin sodium salt dihydrate
- tolmetinum
- tolmetinum
Organizations
Marketing (17)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| ACP Nimble | For profit | MKTG | Mar 28, 1996 |
| ANDA Repository | For profit | MKTG | Nov 27, 1991 |
| Actavis | For profit | MKTG | Jan 24, 1992 |
| Ani Pharmaceuticals | For profit | MKTG | Jan 24, 1992 |
| Ani Pharmaceuticals | For profit | SYN | Jan 24, 1992 |
| Chartwell Pharmaceuticals | For profit | MKTG | Apr 30, 1992 |
| Cosette | For profit | MKTG | Mar 28, 1996 |
| Fosun | For profit | MKTG | Apr 30, 1992 |
| G & W Laboratories Inc. | For profit | MKTG | Mar 28, 1996 |
| Johnson and Johnson | For profit | NDA2 | Mar 24, 1976 |
| Johnson and Johnson | For profit | NDA | Mar 24, 1976 |
| Mylan | For profit | MKTG | May 27, 1993 |
| Rising Pharmaceuticals | For profit | MKTG | May 27, 1993 |
| Senores Pharms | For profit | MKTG | Nov 27, 1991 |
| Sun Pharmaceuticals | For profit | MKTG | Nov 27, 1991 |
| Teva | For profit | MKTG | Jan 24, 1992 |
| Teva | For profit | SYN | Nov 27, 1991 |