phenacemide
Trade name: phenurone
Small moleculeapproved
Approved
Jun 28, 1951
Phenacemide, also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class. Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn from the market because of its severe side effects, which includes personality changes, blood, renal and skin disorders. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- Sodium channel alpha subunitBLOCKER
Sodium channel alpha subunit blocker
- Sodium channel protein type 1 subunit alpha (SCN1A) ↗
- Sodium channel protein type 5 subunit alpha (SCN5A) ↗
- Sodium channel protein type 4 subunit alpha (SCN4A) ↗
- Sodium channel protein type 7 subunit alpha (SCN7A) ↗
- Sodium channel protein type 2 subunit alpha (SCN2A) ↗
- Sodium channel protein type 9 subunit alpha (SCN9A) ↗
- Sodium channel protein type 3 subunit alpha (SCN3A) ↗
- Sodium channel protein type 11 subunit alpha (SCN11A) ↗
- Sodium channel protein type 8 subunit alpha (SCN8A) ↗
- Sodium channel protein type 10 subunit alpha (SCN10A) ↗
- Sodium channel protein type I alpha subunit
- Sodium channel protein type V alpha subunit
- Sodium channel protein type IV alpha subunit
- Sodium channel protein type VII alpha subunit
- Sodium channel protein type IX alpha subunit
- Sodium channel protein type II alpha subunit
- Sodium channel protein type III alpha subunit
- Sodium channel protein type XI alpha subunit
- Sodium channel protein type VIII alpha subunit
- Sodium channel protein type X alpha subunit
- Sodium channel alpha subunits; brain (Types I, II, III)
Approval history
- approvedPriority reviewJun 28, 1951
Chemistry & pharmacology
Loading structure…
SMILES
NC(=O)NC(=O)CC1=CC=CC=C1- Mol. weight
- 178.1879 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral, Topical
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
Yes
Black box warning
Sources
- WikipediaPhenacemide ↗
- NCATSPAI7J52V09 ↗
- ChEMBLCHEMBL918 ↗
- ChEMBLCHEMBL1200945 ↗
Also known as
- benzeneacetamide, n-(aminocarbonyl)-
- cetylureum
- fenacemid
- neophedan
- phacetur
- phenacalum
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacemide
- phenacetur
- phenacetylcarbamide
- phenacetylurea
- phenicarb
- phenuron
- phenuron
- phenuron
- phenuron
- phenuron
- phenuron
- phenurone
- phenurone
- phenurone
- phenurone
- (phenylacetyl)urea
- phetylureum