oxyphenonium
Trade name: antrenyl
Oxyphenonium bromide is a quaternary ammonium anticholinergic agent, which was used under brand name antrenyl, to relieve visceral spasms and as an adjunct in the treatment of peptic ulcer. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. Action is achieved via a dual mechanism: a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and a direct effect upon smooth muscle. Oxyphenonium bromide also been used in the form of eye drops for mydriatic effec — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
- Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Role in regulating gastric secretion, M1 likely involved
- Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Indicated in mydriasis and regulating gastric secretion, M3 likely involved (main form in iris)
Approval history
- approved—
Chemistry & pharmacology
SMILES
CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)C1CCCCC1- Mol. weight
- 348.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1201286 ↗
- WikipediaOxyphenonium bromide ↗
- NCATSD2G5508Y7I ↗
- ChEMBLCHEMBL1200906 ↗
Also known as
- antrenyl
- antrenyl
- antrenyl
- antrenyl
- antrenyl
- antrenyl
- antrenyl
- oxyphenonium
- oxyphenonium
- oxyphenonium
- oxyphenonium
- oxyphenonium
- oxyphenonium
- oxyphenonium
- oxyphenonium bromide
- oxyphenonium bromide
- oxyphenonium bromide
- oxyphenonium bromide
- oxyphenonium cation
- oxyphenonium cation
- oxyphenonium ion
- oxyphenonium ion