hexocyclium methylsulfate
Trade name: tral
Small moleculeapproved
Approved
Feb 13, 1957
Hexocyclium is an old anticholinergic drug. Hexocyclium is an antimuscarinic. Hexocyclium in therapeutic doses produces a prolonged reduction of gastric acidity. It was used for the treatment of peptic ulcer. Hexocyclium is effective for the control of cramps and diarrhea in cases of irritable bowel syndrome. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Role in regulating gastric secretion, M1 likely involved
- Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Role in regulating gastric secretion, M3 likely involved
Approval history
- approvedFeb 13, 1957
Chemistry & pharmacology
Loading structure…
SMILES
C[N+]1(C)CCN(CC(O)(c2ccccc2)C2CCCCC2)CC1- Mol. weight
- 317.5 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1201325 ↗
- WikipediaHexocyclium ↗
- NCATSLL3147PI1T ↗
- ChEMBLCHEMBL1626570 ↗
Also known as
- 4-(2-cyclohexyl-2-hydroxy-2-phenethyl)-1,1- dimethylpiperazinium
- hexociclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium
- hexocyclium methylsulfate
- hexocyclium methylsulfate
- hexocyclium methylsulfate
- hexocyclium methylsulfate
- hexocyclium methylsulfate
- hexocyclium methyl sulfate
- hexocyclium methyl sulfate
- hexocyclium methyl sulfate
- hexocyclium methyl sulfate
- hexocyclium methyl sulfate
- hexocyclium metilsulfate
- hexocyclium metilsulfate
- hexocyclium metilsulfate
- tral
- tral
- tral