diphemanil methylsulfate
Trade name: prantal
Small moleculeapproved
Approved
May 17, 1976
Diphemanil methylsulfate (Prantal), a quarternary amine, is a highly specific parasympathetic blocking agent. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1970s
- Jan 1, 1976
Schering — First NDA Organization
- Jan 1, 1976
Schering — NDA Organization
- May 17, 1976
Earliest FDA Approval
- May 17, 1976
Schering — NDA Secondary Org
- May 17, 1976
Schering-Plough — NDA Secondary Org
Indications
Approved for
Mechanism of action
- Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Role in regulating gastric secretion, M1 likely involved
- Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Role in regulating gastric secretion, M3 likely involved
Approval history
- approvedMay 17, 1976
Chemistry & pharmacology
Loading structure…
SMILES
C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1- Mol. weight
- 278.42 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1201340 ↗
- WikipediaDiphemanil metilsulfate ↗
- NCATSQ26TX1UD0W ↗
- ChEMBLCHEMBL1200880 ↗
Also known as
- 4-(diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate
- 4-(diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate
- biphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanil
- diphemanili metilsulfas
- diphemanili metilsulfas
- diphemanil methosulfate
- diphemanil methosulfate
- diphemanil methosulfate
- diphemanil methylsulfat
- diphemanil methylsulfat
- diphemanil methylsulfate
- diphemanil methylsulfate
- diphemanil methylsulfate
- diphemanil methylsulfate
- diphemanil methylsulfate
- diphemanil methylsulfate
- diphemanil methyl sulfate
- diphemanil metilsulfate
- diphemanil metilsulfate
- diphemanil metilsulfate
- diphemanil metilsulfate
- diphenmanil methylsulfate
- diphenmethanil
- diphenmethanil methylsulfate
- métilsulfate de diphémanil
- métilsulfate de diphémanil
- metilsulfato de difemanilo
- metilsulfato de difemanilo
- n,n-dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate
- n,n-dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate
- p-(alpha-phenylbenzylidene)-1,1-dimethylpiperidinium methyl sulfate
- p-(alpha-phenylbenzylidene)-1,1-dimethylpiperidinium methyl sulfate
- prantal
- prantal
- prantal
- prantal
- vagophemanil
- vagophemanil
Organizations
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Schering | For profit | NDA2 | May 17, 1976 |
| Schering | For profit | NDA | Jan 1, 1976 |
| Schering-Plough | For profit | NDA2 | May 17, 1976 |