cinchocaine
Trade name: nupercaine
Dibucaine is used as a local anesthetic for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. Dibucaine is used to temporarily relieve pain and itching due to: hemorrhoids or other anorectal disorders, sunburn, minor burns, minor cuts; scrapes, insect bites, minor skin irritation. This drug acts via blocking of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel blocking. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
SCN5A blocker
SCN10A blocker
Approval history
- approved—
Chemistry & pharmacology
SMILES
CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1- Mol. weight
- 343.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1086 ↗
- WikipediaCinchocaine ↗
- NCATSL6JW2TJG99 ↗
- ChEMBLCHEMBL2110892 ↗
- ChEMBLCHEMBL2106541 ↗
- ChEMBLCHEMBL1200612 ↗
Also known as
- 2-butoxy-n-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
- 2-butoxy-n-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
- 2-butoxy-n-(2-(diethylamino)ethyl)cinchoninamide
- 2-butoxy-n-(2-(diethylamino)ethyl)cinchoninamide
- 2-butoxy-n-(alpha-diethylaminoethyl)cinchoninamide
- 2-butoxy-n-(alpha-diethylaminoethyl)cinchoninamide
- 2-butoxy-n-(beta-diethylaminoethyl)cinchoninamide
- 2-butoxy-n-(beta-diethylaminoethyl)cinchoninamide
- 2-butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
- 2-butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
- 2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide
- 2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide
- 2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamide
- 2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamide
- alpha-butyloxycinchonic acid-gamma-diethylethylenediamine
- alpha-butyloxycinchonic acid-gamma-diethylethylenediamine
- alpha-butyloxycinchoninic acid diethylethylenediamide
- alpha-butyloxycinchoninic acid diethylethylenediamide
- cincaine chloride
- cincaine chloride
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine
- cinchocaine hcl
- cinchocaine hcl
- cinchocainum
- cinchocainum
- cincocainio
- cincocainio
- dermacaine
- dibucaine
- dibucaine
- dibucaine
- dibucaine
- dibucaine
- dibucaine
- dibucaine base
- dibucaine base
- dibucaine hcl
- dibucaine hcl
- dibucaine hcl
- dibucaine hydrochloride
- dibucaine hydrochloride
- dibucaine hydrochloride
- dibucaine hydrochloride
- heavy solution nupercaine
- heavy solution nupercaine
- n-(2-(diethylamino)ethyl)-2-butoxycinchoninamide
- n-(2-(diethylamino)ethyl)-2-butoxycinchoninamide
- nupercainal
- nupercainal
- nupercaine
- nupercaine
- nupercaine
- nupercaine
- percamine