tumour infiltrating lymphocytes
Cell therapyexperimental
Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. They include T cells and B cells and are part of the larger category of ‘tumor-infiltrating immune cells’ which consist of both mononuclear and polymorphonuclear immune cells, in variable proportions. Their abundance varies with tumor type and stage and in some cases relates to disease prognosis. — Wikipedia
Clinical trial activity
46 trials · 39 clinical orgs · 0 marketing orgs
Phase 1
27
Phase 2
24
Phase 3
1
Phase 4
0
Earliest trial started Jul 1, 1993 (NCT00002535)
Timeline
Indications
Studied for
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 1
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Renal Cell · Phase 1
- Colorectal Neoplasms · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Early Phase 1
- Fallopian Tube Neoplasms · Phase 1
- Gastrointestinal Neoplasms · Phase 1
- Genital Neoplasms, Female · Phase 1
- Hamartoma · Phase 1
- Infections · Phase 1/Phase 2
- Kidney Neoplasms · Phase 2
- Lung Neoplasms · Phase 2
- Lymphocytes · Phase 1
- Lymphocytes, Tumor-Infiltrating · Early Phase 1
- Melanoma · Phase 3
- Multiple Myeloma · Phase 1/Phase 2
- Nasopharyngeal Carcinoma · Phase 2
- Neoplasms · Phase 2
- Ovarian Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 2
- Platinum · Phase 1
- Skin Neoplasms · Phase 2
- Uterine Cervical Neoplasms · Phase 2
Mechanism of action
- Tumor antigensImmunity, passive
Tumor antigens immunity, passive
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTumor-infiltrating lymphocytes ↗
Also known as
- tumor infiltrating lymphocyte
- tumor infiltrating lymphocytes
- tumor-infiltrating lymphocytes
- tumour infiltrating lymphocytes
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06630611 | Phase 2 | Dec 31, 2024 | Banc de Sang i Teixits, Universidad Autonoma de Barcelona |
| NCT06626256 | Phase 1 | Dec 30, 2024 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT06375187 | Phase 1 | May 29, 2024 | Government of China |
| NCT06047977 | Phase 1 | Feb 1, 2024 | Cannonball Kids' Cancer Foundation, Johns Hopkins University, Swim Across America, University of South Florida |
| NCT06107894 | Phase 1 | Jan 31, 2024 | Neogen, University of Ulsan |
| NCT05649618 | Early Phase 1 (Phase 1) | Dec 5, 2022 | Fujian Medical University |
| NCT05087745 | Early Phase 1 (Phase 1) | Dec 10, 2021 | Shanghai Gencells Therapeutics Co., Ltd., Zhejiang University |
| NCT03526185 | Early Phase 1 (Phase 1) | Feb 6, 2018 | Yale University |
| NCT03166397 | Phase 2 | Jun 1, 2017 | Tel Aviv University |
| NCT03158935 | Phase 1 | Jun 1, 2017 | Merck, University of Toronto |
| NCT02926053 | Phase 1 | Dec 1, 2016 | University of Copenhagen |
| NCT02652455 | Early Phase 1 (Phase 1) | Mar 2, 2016 | Bristol-Myers Squibb, Iovance, Prometheus Inc., University of South Florida |
| NCT02500576 | Phase 2 | Aug 7, 2015 | Merck, Prometheus Inc., University of Texas at Houston |
| NCT02482090 | Phase 1 | Jul 1, 2015 | University of Copenhagen |
| NCT02421640 | Phase 2 | Mar 1, 2015 | Sun Yat-Sen University |
| NCT01883297 | Phase 1 | Jan 1, 2015 | University of Toronto |
| NCT02379195 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2014 | University of Copenhagen |
| NCT02354690 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2014 | University of Copenhagen |
| NCT01995344 | Phase 2 | Oct 1, 2013 | National Institute for Health Research, United Kingdom, The Christie NHS Foundation Trust, University of Manchester |
| NCT01807182 | Phase 2 | Jul 26, 2013 | National Cancer Institute (NCI), University of Washington |
Showing 20 of 46 trials
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Organizations
Research & Development (39)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 18 | 7 | 2 | 1994 |
| National Institutes of Health (NIH) | Government | 7 | 4 | 2 | 2003 |
| University of South Florida | Academic/Hospital | 5 | 5 | 3 | 2009 |
| University of Copenhagen | Academic/Hospital | 4 | 4 | 2 | 2014 |
| University of Washington | Academic/Hospital | 3 | 3 | 2 | 1995 |
| Bristol-Myers Squibb | For profit | 2 | 0 | 2 | 2012 |
| Iovance | For profit | 2 | 0 | 2 | 2012 |
| Johns Hopkins University | Academic/Hospital | 2 | 2 | 2 | 2007 |
| Merck | For profit | 2 | 0 | 2 | 2015 |
| Prometheus Inc. | For profit | 2 | 0 | 2 | 2015 |
| Sun Yat-Sen University | Academic/Hospital | 2 | 2 | 2 | 2011 |
| University of Toronto | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Banc de Sang i Teixits | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Cancer Biotherapy Research Group | Academic/Hospital | 1 | 0 | 1 | 1996 |
| Cannonball Kids' Cancer Foundation | Academic/Hospital | 1 | 0 | 1 | 2024 |
| City of Hope National Medical Center | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Fujian Medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Government of China | Government | 1 | 1 | 1 | 2024 |
| Hebrew University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Hoag Memorial Hospital Presbyterian | Academic/Hospital | 1 | 1 | 1 | 1996 |
39 organizations
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