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obatoclax

Small moleculeexperimental

Obatoclax mesylate, also known as GX15-070, is an experimental drug for the treatment of various types of cancer. It was discovered by Gemin X, which was acquired by Cephalon, which has since been acquired by Teva Pharmaceuticals. Several Phase II clinical trials were completed that investigated use of obatoclax in the treatment of leukemia, lymphoma, myelofibrosis, and mastocytosis. — Wikipedia

Clinical trial activity

19 trials · 9 clinical orgs · 0 marketing orgs

Phase 1
12
Phase 2
14
Phase 3
1
Phase 4
0

Earliest trial started Sep 1, 2004 (NCT00600964)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2012

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COC1=CC(c2cc3ccccc3[nH]2)=N/C1=C\c1[nH]c(C)cc1C
Mol. weight
317.39 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • gx015-070
  • gx 15-070
  • gx-15-070
  • gx15-070
  • gx15-070ms
  • gx15-070ms
  • gx15-070ms
  • obatoclax
  • obatoclax
  • obatoclax
  • obatoclax
  • obatoclax
  • obatoclax mesylate
  • obatoclax mesylate
  • obatoclax mesylate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01563601Phase 3Aug 1, 2012Cephalon
NCT01238146Phase 1/Phase 2 (Phase 2)Oct 1, 2010National Cancer Institute (NCI), Ohio State University
NCT00933985Phase 1Jun 1, 2009National Cancer Institute (NCI)
NCT00918931Phase 2Jun 1, 2009Gemin X, University of Texas at Houston
NCT00719901Phase 1/Phase 2 (Phase 2)Jul 1, 2008Mayo Clinic, National Cancer Institute (NCI)
NCT00724841Phase 1/Phase 2 (Phase 2)Jun 1, 2008Gemin X
NCT00682981Phase 1/Phase 2 (Phase 2)May 1, 2008Cephalon, Gemin X
NCT00684918Phase 2Apr 1, 2008Gemin X
NCT00612612Phase 1Jan 1, 2008Harvard University, National Cancer Institute (NCI)
NCT00538187Phase 1Dec 1, 2007City of Hope National Medical Center, National Cancer Institute (NCI)
NCT00521144Phase 1/Phase 2 (Phase 2)Aug 1, 2007Cornell University, National Cancer Institute (NCI)
NCT00427856Phase 2Mar 1, 2007Gemin X
NCT00413114Phase 2Dec 1, 2006Gemin X
NCT00407303Phase 1/Phase 2 (Phase 2)Oct 1, 2006Gemin X
NCT00405951Phase 1/Phase 2 (Phase 2)Oct 1, 2006Gemin X
NCT00359892Phase 2Jul 1, 2006Gemin X
NCT00360035Phase 2Jul 1, 2006Gemin X
NCT00438178Phase 1Oct 1, 2005Gemin X
NCT00600964Phase 1Sep 1, 2004Gemin X
Showing 19 of 19 trials
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Organizations

Research & Development (9)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Gemin XFor profit121122004
National Cancer Institute (NCI)Government6622007
CephalonFor profit2122008
City of Hope National Medical CenterAcademic/Hospital1012007
Cornell UniversityAcademic/Hospital1012007
Harvard UniversityAcademic/Hospital1012008
Mayo ClinicAcademic/Hospital1012008
Ohio State UniversityAcademic/Hospital1012010
University of Texas at HoustonAcademic/Hospital1112009
9 organizations
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