hypochlorous acid
Small moleculeexperimental
CALCIUM CHLORIDE HYDROXIDE HYPOCHLORITE, DIHYDRATE is an inert ingredient in pesticide products. — NCATS
Clinical trial activity
80 trials · 70 clinical orgs · 0 marketing orgs
Phase 1
9
Phase 2
11
Phase 3
8
Phase 4
11
Earliest trial started Sep 1, 2005 (NCT00179959)
Timeline
Indications
Approved for
Studied for
- Cataract · Phase 3
- Chemical Actions and Uses · Early Phase 1
- Communicable Diseases · Phase 3
- Coronavirus · Phase 4
- COVID-19 · Phase 4
- Dental Pulp · Phase 4
- Dental Pulp Diseases · Phase 4
- Dental Pulp Necrosis · Phase 4
- Dermatitis · Phase 2
- Dermatitis, Atopic · Phase 4
- Dermatology · Phase 4
- Diabetic Retinopathy · Phase 4
- Eczema · Phase 2
- Endophthalmitis · Phase 3
- Eye Infections, Bacterial · Phase 4
- Hypochlorous Acid · Phase 2
- Infections · Phase 1
- Inflammation · Phase 2
- Irritants · Phase 1
- Leg Ulcer · Phase 1
- Lymphoma · Phase 2
- Macular Degeneration · Phase 4
- Macular Edema · Phase 4
- Mouthwashes · Phase 4
- Neoplasms · Phase 2
- Periapical Periodontitis · Phase 4
- Polymerase Chain Reaction · Phase 4
- Postoperative Pain · Phase 4
- Pressure Ulcer · Phase 4
- Pulpitis · Phase 3
- Radiodermatitis · Phase 3
- Saliva · Phase 4
- SARS-CoV-2 · Phase 4
- Severe Acute Respiratory Syndrome · Phase 2/Phase 3
- Skin Diseases · Phase 2
- Skin Diseases, Genetic · Phase 2
- Spinal Cord Injuries · Phase 4
- Squamous Cell Carcinoma of Head and Neck · Phase 3
- Surgical Wound Infection · Phase 2
- Tooth, Nonvital · Phase 2
- Viral Load · Phase 4
- Virus Diseases · Phase 2/Phase 3
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
OCl- Mol. weight
- 52.46 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1616046 ↗
- WikipediaHypochlorite ↗
- NCATS712K4CDC10 ↗
- ChEMBLCHEMBL1334078 ↗
- WikipediaHypochlorous acid ↗
Also known as
- antiformin, dental
- antiformin, dental
- chlorasol
- dental antiformin
- dental antiformin
- hypchlorous acid
- hypochlorite
- hypochlorite
- hypochlorite
- hypochlorous acid
- hypochlorous acid
- hypochlorous acid
- milton in emuls wax
- milton in liq paraf
- milton no.2
- sodium hypochloride
- sodium hypochlorite
- sodium hypochlorite
- sodium hypochlorite
- sodium hypochlorite
- sodium hypochlorite
- sodium hypochlorite
- sodium hypochlorite [solution, diluted]
- sodium hypochlorite [solution, diluted]
- sodium oxychloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07287709 | N/A | Nov 7, 2025 | Alexandria University |
| NCT07248189 | Early Phase 1 (Phase 1) | Nov 1, 2025 | Cairo University, Egyptian Russian University |
| NCT07025525 | N/A | Aug 31, 2025 | Cairo University |
| NCT07058727 | N/A | Aug 1, 2025 | Cukurova University |
| NCT06971055 | N/A | Jul 20, 2025 | Cairo University |
| NCT06969989 | N/A | Jul 1, 2025 | Cairo University |
| NCT06948526 | N/A | Jun 1, 2025 | Cairo University |
| NCT07048028 | N/A | May 5, 2025 | T.C. Ordu Universitesi |
| NCT06811779 | Phase 1 | Mar 24, 2024 | Government of Pakistan |
| NCT06949176 | N/A | Dec 1, 2023 | University of Athens |
| NCT06116214 | Phase 4 | Nov 30, 2023 | Cairo University |
| NCT05959629 | N/A | Nov 30, 2023 | University of Pennsylvania |
| NCT05988788 | N/A | Oct 31, 2023 | Cairo University |
| NCT07071467 | N/A | Sep 1, 2023 | Alexandria University |
| NCT06760403 | N/A | May 2, 2023 | Ataturk University |
| NCT05974748 | Phase 3 | Apr 1, 2023 | Dow University of Health Sciences |
| NCT06002646 | Phase 4 | Jan 4, 2023 | University of Sulaimani |
| NCT05614154 | N/A | Nov 4, 2022 | Ataturk University |
| NCT05348824 | Phase 2/Phase 3 (Phase 3) | Aug 31, 2022 | Cairo University |
| NCT05306431 | Phase 2 | Aug 1, 2022 | Altamash Institute of Dental Medicine |
Showing 20 of 80 trials
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Organizations
Research & Development (70)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 16 | 16 | 4 | 2011 |
| Ataturk University | Academic/Hospital | 3 | 3 | 2 | 2021 |
| National Cancer Institute (NCI) | Government | 3 | 1 | 3 | 2012 |
| Alexandria University | Academic/Hospital | 2 | 2 | 1 | 2023 |
| Cukurova University | Academic/Hospital | 2 | 2 | 1 | 2014 |
| Dow University of Health Sciences | Academic/Hospital | 2 | 2 | 2 | 2021 |
| Harvard University | Academic/Hospital | 2 | 2 | 2 | 2020 |
| Northwestern University | Academic/Hospital | 2 | 2 | 2 | 2005 |
| Realm Therapeutics | For profit | 2 | 1 | 2 | 2009 |
| Stanford University | Academic/Hospital | 2 | 2 | 2 | 2014 |
| University of Arizona | Academic/Hospital | 2 | 2 | 1 | 2009 |
| University of Miami | Academic/Hospital | 2 | 2 | 2 | 2016 |
| University of Pennsylvania | Academic/Hospital | 2 | 2 | 2 | 2020 |
| Washington University in St. Louis | Academic/Hospital | 2 | 2 | 1 | 2007 |
| Yuzuncu Yıl University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Altamash Institute of Dental Medicine | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Antisepsia Central | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Association of Paediatric and Preventive Dentists of Serbia | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Bio-Science Laboratories | For profit | 1 | 0 | 1 | 2014 |
| California Retina Consultants | Academic/Hospital | 1 | 1 | 1 | 2019 |
70 organizations
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