methyl salicylate

Small moleculeapproved

Approved

Feb 20, 2008

Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer (in which it is used as a flavoring), but often associatively called "minty", as it is an ingredient in mint candies. It is produced by many species of plants, particularly wintergreens. It is also produced synthetically, used as a fragrance and as a flavoring agent. — Wikipedia

Clinical trial activity

6 trials · 8 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Apr 7, 2009 (NCT03362216)

Timeline

2000s

Feb 20, 2008
Hisamitsu Pharmaceutical Co., Inc. — Earliest FDA Approval
Feb 20, 2008
Hisamitsu Pharmaceutical Co., Inc. — NDA Secondary Org
Feb 20, 2008
Hisamitsu Pharmaceutical Co., Inc. — NDA Organization

2010s

Jan 1, 2015
Earliest Phase 1 Sponsor(trial)

2020s

Jan 1, 2022
Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Unspecified targetOTHER
Unknown

Combination products

salonpas
with menthol

Approval history

approvedFeb 20, 2008

Chemistry & pharmacology

Loading structure…

SMILES

COC(=O)c1ccccc1O

Mol. weight: 152.15 g/mol
Lipinski Ro5: Pass
Rule of 3: Yes
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Topical
Availability: Over the Counter

Oral

Parenteral

Topical

Yes

Sources

WikipediaMethyl salicylate ↗
ChEMBLCHEMBL108545 ↗

Also known as

2-carbomethoxyphenol
2-carbomethoxyphenol
2-hydroxybenzoic acid methyl ester
2-hydroxybenzoic acid methyl ester
2-(methoxycarbonyl)phenol
2-(methoxycarbonyl)phenol
analgit
aspellin
balmosa
bengue's balsam
betula oil
betula oil
betula oil
birch oil, sweet
birch oil, sweet
deep heat
deep heat
dubam
gaultheria
gaultheria
gaultheria oil
gaultheria oil
gaultheria oil
gppe lin
gppe rub
hewedolor
linsal
luma
luma
menthyl salicylate
menthyl salicylate
menthyl salicylate, (+/-)-
menthyl salicylate, (+/-)-
methyl 2-hydroxybenzoate
methyl 2-hydroxybenzoate
methyl 2-hydroxybenzoate
methyl ester 2-hydroxy benzoic acid
methyl o-hydroxybenzoate
methyl o-hydroxybenzoate
methylsalicylate
methylsalicylate
methylsalicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate
methyl salicylate sodium salt
metsal liniment
nasciodine
natural wintergreen oil
natural wintergreen oil
oil of wintergreen
oil of wintergreen
oil of wintergreen
p.r.
p.r.
radian-b
rheumabal
rhodiaflor
sloans
spicewood oil
spicewood oil
sweet birch oil
sweet birch oil
sweet birch oil
teaberry oil
teaberry oil
teaberry oil
thera-gesic
wintergreen
wintergreen
wintergreen oil
wintergreen oil
wintergreen oil

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT05411913	Phase 3	Jul 1, 2022	Apothyx, Co.
NCT04900129	Phase 1	Dec 1, 2020	Sher-E-Bangla Medical College
NCT02400320	Phase 4	Mar 1, 2016	GlaxoSmithKline
NCT02874963	N/A	Nov 1, 2015	University Clinical Centre of Kosova, University of Ljubljana
NCT02666846	Phase 1	Mar 1, 2015	Futura Medical Developments Ltd., Parexel
NCT03362216	N/A	Apr 7, 2009	Peking University

Showing 6 of 6 trials

Page 1 / 1

Organizations

Research & Development (8)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Apothyx, Co.	For profit	1	1	1	2022
Futura Medical Developments Ltd.	For profit	1	1	1	2015
GlaxoSmithKline	For profit	1	1	1	2016
Parexel	For profit	1	0	1	2015
Peking University	Academic/Hospital	1	1	1	2009
Sher-E-Bangla Medical College	Academic/Hospital	1	1	1	2020
University Clinical Centre of Kosova	Academic/Hospital	1	1	1	2015
University of Ljubljana	Academic/Hospital	1	0	1	2015

8 organizations

Page 1 / 1

Marketing (2)

Organization	Org type	Relationship	Date
Hisamitsu Pharmaceutical Co., Inc.	For profit	NDA2	Feb 20, 2008
Hisamitsu Pharmaceutical Co., Inc.	For profit	NDA	Feb 20, 2008