superoxide dismutase
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. — Wikipedia
Clinical trial activity
10 trials · 12 clinical orgs · 0 marketing orgs
Earliest trial started Nov 1, 2005 (NCT00618917)
Timeline
Indications
Approved for
Studied for
- Diabetes Mellitus · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 1/Phase 2
- Esophageal Diseases · Phase 1/Phase 2
- Frail Elderly · Phase 4
- Hypersensitivity · Phase 4
- Pulmonary Disease, Chronic Obstructive · Phase 2
- Renal Dialysis · Phase 4
- Severe acute respiratory syndrome-related coronavirus · Phase 4
- Sleep Apnea Syndromes · Early Phase 1
- Vaccines · Phase 4
- Virus Diseases · Phase 4
Mechanism of action
- Unspecified targetAntioxidant
antioxidant
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSOD2 ↗
- NCATSW2T4YRA9AD ↗
- WikipediaSuperoxide dismutase ↗
Also known as
- mnsod
- superoxide dismutase
- superoxide dismutase
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06131918 | Phase 2 | Jan 9, 2023 | Khyber Medical University Peshawar, Khyber Medical University Peshawer |
| NCT05711810 | Phase 4 | Jan 2, 2023 | University of Pennsylvania |
| NCT04919850 | N/A | Jan 15, 2018 | University of Pavia |
| NCT02880657 | N/A | Sep 1, 2016 | Bionov, Hospital Purpan |
| NCT02753582 | Phase 4 | Apr 1, 2016 | University of Indonesia |
| NCT02774226 | Phase 2 | Sep 1, 2015 | Augusta University |
| NCT02115724 | N/A | Apr 1, 2014 | Augusta University, National Heart, Lung, and Blood Institute (NHLBI) |
| NCT01398943 | N/A | Sep 1, 2010 | American Heart Association, Augusta University |
| NCT00860743 | Early Phase 1 (Phase 1) | Sep 1, 2009 | Department of Veteran Affairs |
| NCT00618917 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2005 | University of Pittsburgh |
Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Augusta University | Academic/Hospital | 3 | 3 | 2 | 2010 |
| American Heart Association | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Bionov | For profit | 1 | 1 | 1 | 2016 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2009 |
| Hospital Purpan | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Khyber Medical University Peshawar | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Khyber Medical University Peshawer | Academic/Hospital | 1 | 0 | 1 | 2023 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2014 |
| University of Indonesia | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Pavia | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Pennsylvania | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Pittsburgh | Academic/Hospital | 1 | 1 | 1 | 2005 |