amonafide

Small moleculeexperimental

Amonafide was a drug that was being studied in the treatment of cancer. It belongs to a novel family of chemotherapeutic drugs called Naphthalimides and is a potential topoisomerase inhibitor and DNA intercalator. — Wikipedia

Clinical trial activity

4 trials · 4 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Mar 1, 2004 (NCT00087854)

Timeline

2000s

Jan 1, 2004
Earliest Phase 1 Sponsor(trial)
Jan 1, 2005
Earliest Phase 2 Sponsor(trial)
Jan 1, 2007
Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Topoisomerase I/IIINHIBITOR
Topoisomerase I/II inhibitor
- DNA topoisomerase 1 (TOP1) ↗
- DNA topoisomerase 2-alpha (TOP2A) ↗
- DNA topoisomerase I
- DNA topoisomerase II alpha

Chemistry & pharmacology

Loading structure…

SMILES

CN(C)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O

Mol. weight: 283.33 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

WikipediaAmonafide ↗
ChEMBLCHEMBL428676 ↗

Also known as

1h-benz(de)isoquinoline-1,3(2h)-dione, 5-amino-2-(2-(dimethylamino)ethyl)-
5-amino-2-(2-dimethylaminoethyl)benzo(de)isoquinolin-1,3-dione
amonafide
amonafide
amonafide
amonafide
amonafide
amonafide l-malate
amonafide l-malate
as-1413
as-1413
benzisoquinolinedione
fa 142
m-fa 142
m-fa-142
mfa 142
mfa-142
nafidimide
nsc 308847
nsc-308847

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT01066494	Phase 2	Jan 1, 2010	Antisoma Research
NCT00715637	Phase 3	Jun 1, 2007	Antisoma Research
NCT00273884	Phase 2	Aug 1, 2005	North Shore Hospital, New Zealand, Xanthus Pharmaceuticals, Inc.
NCT00087854	Phase 1/Phase 2 (Phase 2)	Mar 1, 2004	Johns Hopkins University, Xanthus Pharmaceuticals, Inc.

Showing 4 of 4 trials

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Organizations

Research & Development (4)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Antisoma Research	For profit	2	2	2	2007
Xanthus Pharmaceuticals, Inc.	For profit	2	2	1	2004
Johns Hopkins University	Academic/Hospital	1	0	1	2004
North Shore Hospital, New Zealand	Academic/Hospital	1	0	1	2005

4 organizations

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