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90-yttrium

Small moleculeexperimental

Yttrium-90 is a radioactive isotope of yttrium. Yttrium-90 has found a wide range of uses in radiation therapy to treat some forms of cancer. It is sometimes called radioyttrium. — Wikipedia

Clinical trial activity

22 trials · 30 clinical orgs · 0 marketing orgs

Phase 1
10
Phase 2
10
Phase 3
2
Phase 4
0

Earliest trial started Jan 1, 2004 (NCT00683631)

Timeline

2000s

  1. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2012

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2013

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetRadiodepletion

    radiodepletion

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • sir-spheres
  • therasphere
  • y90 microspheres
  • yttrium
  • yttrium
  • yttrium-90
  • yttrium-90
  • yttrium-90
  • yttrium (90 y)
  • yttrium (90 y)
  • yttrium [90y] chloride
  • yttrium y 90
  • yttrium y 90
  • yttrium y-90
  • yttrium y-90

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06900543Phase 3Apr 15, 2025Government of China, Southeast University
NCT06725121Phase 1/Phase 2 (Phase 2)Dec 31, 2024University of Toronto
NCT06555133Phase 2Dec 30, 2024Brown University, Genentech, Sirtex Medical
NCT06278454Phase 1Sep 30, 2024Changhai Hospital, Government of China
NCT06310590Phase 1Aug 8, 2023Government of China, Southeast University
NCT05957640Phase 1May 5, 2023Southeast University
NCT05692037Phase 1/Phase 2 (Phase 2)Dec 28, 2022Southeast University
NCT05620771Phase 2Nov 25, 2022National Cancer Institute (NCI), Northwestern University
NCT05377034Phase 2Aug 25, 2022Government of Singapore, Roche, Singapore Clinical Research Institute, Sirtex Medical
NCT04518748Phase 1Sep 16, 2020Department of Health and Human Services, University of Michigan
NCT03889093N/AAug 9, 2018University of Minnesota
NCT03300401N/ANov 7, 2017National Cancer Institute (NCI), University of Southern California
NCT02859064Phase 2Jun 1, 2017Ipsen, SCRI Development Innovations
NCT02288507Phase 1Nov 1, 2014University of Hawaii
NCT01864070Phase 1May 1, 2014BTG, Novartis, University of Texas at Houston
NCT01900002Phase 2Sep 13, 2013Bayer, University of Texas at Houston
NCT01887717Phase 3Jun 1, 2013Biocompatibles International plc, BTG, Northwestern University, University of Milan
NCT01581307Phase 2Apr 1, 2012BTG, University of South Florida
NCT02248298Phase 1Jan 1, 2012Dong-A University
NCT00846131Phase 1Feb 1, 2009National Cancer Institute (NCI), Northwestern University
Showing 20 of 22 trials
Page 1 / 2

Organizations

Research & Development (30)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Southeast UniversityAcademic/Hospital4232022
BTGFor profit3132012
Government of ChinaGovernment3322023
National Cancer Institute (NCI)Government3032009
Northwestern UniversityAcademic/Hospital3232009
Sirtex MedicalFor profit2012022
University of Texas at HoustonAcademic/Hospital2222013
BayerFor profit1012013
Biocompatibles International plcFor profit1012013
Brown UniversityAcademic/Hospital1112024
Changhai HospitalAcademic/Hospital1012024
Department of Health and Human ServicesGovernment1012020
Dong-A UniversityAcademic/Hospital1112012
GenentechFor profit1012024
Government of SingaporeGovernment1112022
IpsenFor profit1012017
MDS PharmaFor profit1012004
NovartisFor profit1012014
RocheFor profit1012022
SCRI Development InnovationsFor profit1112017
30 organizations
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