sodium phosphosilicate
Small moleculeexperimental
Bioglass 45S5 or calcium sodium phosphosilicate, is a bioactive glass specifically composed of 45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O, and 6.0 wt% P2O5. Typical applications of Bioglass 45S5 include: bone grafting biomaterials, repair of periodontal defects, cranial and maxillofacial repair, wound care, blood loss control, stimulation of vascular regeneration, and nerve repair. — Wikipedia
Clinical trial activity
7 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2012 (NCT01657877)
Timeline
Indications
Mechanism of action
- CalciumSupplementation
Calcium supplementation
Chemistry & pharmacology
Loading structure…
SMILES
P.P.[Ca+2].[Na+].[Na+].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[SiH4]- Mol. weight
- 330.16 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBioglass 45S5 ↗
- ChEMBLCHEMBL6067999 ↗
- ChEMBLCHEMBL4650384 ↗
Also known as
- calcium sodium phosphosilicate
- sodium phosphosilicate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07300540 | N/A | Dec 31, 2025 | Citruslabs, Healeon Medical Inc |
| NCT06273930 | Phase 1 | Feb 1, 2024 | Government of Pakistan |
| NCT03741309 | Phase 2 | Dec 20, 2017 | Government Dental College and Research Institute, Bangalore |
| NCT03285360 | Phase 1 | Oct 1, 2017 | Cairo University |
| NCT01831817 | Phase 2 | Jan 1, 2013 | GlaxoSmithKline |
| NCT01691560 | Phase 2 | Aug 1, 2012 | BioSci Research, GlaxoSmithKline |
| NCT01657877 | Phase 2 | May 1, 2012 | GlaxoSmithKline |
Showing 7 of 7 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 3 | 3 | 1 | 2012 |
| BioSci Research | For profit | 1 | 0 | 1 | 2012 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Citruslabs | For profit | 1 | 0 | 1 | 2025 |
| Government Dental College and Research Institute, Bangalore | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Government of Pakistan | Government | 1 | 1 | 1 | 2024 |
| Healeon Medical Inc | For profit | 1 | 1 | 1 | 2025 |
7 organizations
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