← Mechanisms of action
26S proteosome
PROTEIN COMPLEXHomo sapiens
Linked proteins
- 26S proteasome non-ATPase regulatory subunit 1 (PSMD1) ↗
- Proteasome subunit beta type-2 (PSMB2) ↗
- Proteasome subunit beta type-1 (PSMB1) ↗
- Proteasome subunit beta type-5 (PSMB5) ↗
- Proteasome subunit beta type-8 (PSMB8) ↗
- Proteasome subunit beta type-9 (PSMB9) ↗
- Proteasome subunit beta type-6 (PSMB6) ↗
- 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) ↗
- Proteasome subunit alpha-type 8 (PSMA8) ↗
- Proteasome subunit alpha type-1 (PSMA1) ↗
- Proteasome subunit alpha type-2 (PSMA2) ↗
- Proteasome subunit alpha type-3 (PSMA3) ↗
- Proteasome subunit alpha type-4 (PSMA4) ↗
- Proteasome subunit alpha type-5 (PSMA5) ↗
- Proteasome subunit alpha type-6 (PSMA6) ↗
- Proteasome subunit alpha type-7 (PSMA7) ↗
- Proteasome subunit beta type-10 (PSMB10) ↗
- Proteasome subunit beta type-11 (PSMB11) ↗
- Proteasome subunit beta type-3 (PSMB3) ↗
- Proteasome subunit beta type-4 (PSMB4) ↗
- Proteasome subunit beta type-7 (PSMB7) ↗
- Proteasomal ubiquitin receptor ADRM1 (ADRM1) ↗
- 26S proteasome non-ATPase regulatory subunit 3 (PSMD3) ↗
- 26S proteasome regulatory subunit 7 (PSMC2) ↗
- 26S proteasome regulatory subunit 4 (PSMC1) ↗
- 26S proteasome regulatory subunit 6B (PSMC4) ↗
- 26S proteasome regulatory subunit 10B (PSMC6) ↗
- 26S proteasome regulatory subunit 6A (PSMC3) ↗
- 26S proteasome regulatory subunit 8 (PSMC5) ↗
- 26S proteasome non-ATPase regulatory subunit 2 (PSMD2) ↗
- 26S proteasome non-ATPase regulatory subunit 12 (PSMD12) ↗
- 26S proteasome non-ATPase regulatory subunit 11 (PSMD11) ↗
- 26S proteasome non-ATPase regulatory subunit 6 (PSMD6) ↗
- 26S proteasome non-ATPase regulatory subunit 7 (PSMD7) ↗
- 26S proteasome non-ATPase regulatory subunit 13 (PSMD13) ↗
- 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) ↗
- 26S proteasome non-ATPase regulatory subunit 8 (PSMD8) ↗
- 26S proteasome complex subunit SEM1 (SEM1) ↗
Drugs acting on this target (4)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| bortezomib (velcade) | Inhibitor | approved | Small molecule | 26S proteosome inhibitor |
| carfilzomib (kyprolis) | Inhibitor | approved | Small molecule | 26S proteosome inhibitor |
| ixazomib (ninlaro) | Inhibitor | approved | Small molecule | 26S proteosome inhibitor |
| oprozomib | Inhibitor | experimental | Small molecule | 26S proteosome inhibitor |