← Mechanisms of action
IL6
SINGLE PROTEINHomo sapiens
Preferred name: Interleukin-6 ChEMBL ↗
Linked proteins
Drugs acting on this target (27)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| CLB IL6/8 | Antagonist | experimental | mAb | IL6 |
| olamkicept | Antagonist | experimental | Recombinant protein | IL6 antagonist |
| recombinant humanized anti-interleukin-6 receptor monoclonal antibody | Antagonist | experimental | mAb | IL6 |
| siltuximab (sylvant) | Antagonist | approved | mAb | Interleukin-6 inhibitor |
| tj301 | Antagonist | experimental | Peptide | IL6 antagonist |
| ziltivekimab | Binding agent | experimental | mAb | Interleukin-6 binding agent |
| clazakizumab | Inhibitor | experimental | mAb | IL6 inhibitor |
| ebi-031 | Inhibitor | experimental | mAb | IL6 inhibitor |
| elsilimomab | Inhibitor | experimental | mAb | IL6 inhibitor |
| fb704a | Inhibitor | experimental | mAb | IL6 inhibitor |
| gerilimzumab | Inhibitor | experimental | mAb | IL6 inhibitor |
| ksi-101 | Inhibitor | experimental | Recombinant protein | IL6 inhibitor |
| medi-5117 | Inhibitor | experimental | mAb | IL6 inhibitor |
| medi7219 | Inhibitor | experimental | mAb | IL6 inhibitor |
| mra 003 | Inhibitor | experimental | mAb | IL6 inhibitor |
| olokizumab | Inhibitor | experimental | mAb | IL6 inhibitor |
| pf-04236921 | Inhibitor | experimental | mAb | IL6 inhibitor |
| pf-07314470 | Inhibitor | experimental | mAb | IL6 inhibitor |
| sarilumab (kevzara) | Inhibitor | approved | mAb | IL6 inhibitor |
| siltuximab (sylvant) | Inhibitor | approved | mAb | IL6 inhibitor |
| sirukumab | Inhibitor | experimental | mAb | IL6 inhibitor |
| tour006 | Inhibitor | experimental | mAb | IL6 inhibitor |
| ziltivekimab | Inhibitor | experimental | mAb | IL6 inhibitor |
| adenoviral-mediated interferon-beta | Supplementation | experimental | Gene therapy | IL6 supplementation |
| art-i02 | Supplementation | experimental | Gene therapy | IL6 supplementation |
| interleukin-6 | Supplementation | experimental | Recombinant protein | IL6 supplementation |
| son-080 | Supplementation | experimental | Recombinant protein | IL6 supplementation |