← Mechanisms of action
PKLR
SINGLE PROTEINHomo sapiens
Preferred name: Pyruvate kinase isozymes R/L ChEMBL ↗
Linked proteins
Drugs acting on this target (9)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| ag-946 | Activator | experimental | Small molecule | PKLR activator |
| etavopivat | Activator | experimental | Small molecule | Pyruvate kinase isozymes R/L activator |
| mitapivat (Pyrukynd) | Activator | approved | Small molecule | Pyruvate kinase isozymes R/L activator |
| tebapivat | Activator | experimental | Small molecule | PKLR activator |
| nitrendipine | Antagonist | experimental | Small molecule | PKLR antagonist |
| etavopivat | Inhibitor | experimental | Small molecule | PKLR inhibitor |
| pyruvate | Substrate | experimental | Small molecule | PKLR substrate |
| rp-l301 | Supplementation | experimental | Gene therapy | PKLR supplementation |
| rp-l401 | Supplementation | experimental | Cell therapy | PKLR supplementation |