nitrendipine
Small moleculeexperimental
Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine. — Wikipedia
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
1
Phase 4
3
Earliest trial started Feb 1, 1990 (NCT02088450)
Timeline
Indications
Approved for
Mechanism of action
- Pyruvate kinase isozymes R/LANTAGONIST
PKLR antagonist
Voltage-gated L-type calcium channel blocker
Chemistry & pharmacology
Loading structure…
SMILES
CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1- Mol. weight
- 360.37 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaNitrendipine ↗
- ChEMBLCHEMBL475534 ↗
Also known as
- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
- bay e 5009
- bay e 5009
- bay-e-5009
- bay-e-5009
- bayotensin
- bayotensin
- baypress
- baypress
- baypress
- bylotensin
- bylotensin
- deiten
- deiten
- nidrel
- nidrel
- nitrendipin
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipine
- nitrendipino
- nitrendipino
- nitrendipinum
- nitrendipinum
- nitrepin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04931108 | Phase 4 | Jun 30, 2021 | Jiao Tong University |
| NCT02217852 | Phase 4 | Aug 1, 2014 | Sichuan University |
| NCT04371874 | N/A | Jan 31, 2014 | Jiao Tong University |
| NCT00892892 | Phase 4 | Nov 1, 2009 | University of Erlangen-Nuremberg |
| NCT00751829 | Phase 3 | Jul 1, 2003 | Daiichi Sankyo, IMFORM GmbH |
| NCT02088450 | Phase 2 | Feb 1, 1990 | Katholieke Universiteit Leuven |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Jiao Tong University | Academic/Hospital | 2 | 2 | 2 | 2014 |
| Daiichi Sankyo | For profit | 1 | 1 | 1 | 2003 |
| IMFORM GmbH | For profit | 1 | 0 | 1 | 2003 |
| Katholieke Universiteit Leuven | Academic/Hospital | 1 | 1 | 1 | 1990 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| University of Erlangen-Nuremberg | Academic/Hospital | 1 | 1 | 1 | 2009 |
6 organizations
Page 1 / 1