CDEK
← Mechanisms of action

IGF1R

SINGLE PROTEINHomo sapiens
Preferred name: Insulin-like growth factor I receptor ChEMBL ↗

Linked proteins

Drugs acting on this target (54)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
bionetideAgonistexperimentalPeptideIGF1R agonist
igf-methotrexateAgonistexperimentalRecombinant proteinIGF1R agonist
insulin glulisine (Apidra)AgonistapprovedRecombinant proteinIGF1R agonist
mecasermin (Increlex)AgonistapprovedRecombinant proteinIGF1R agonist
na-931AgonistexperimentalSmall moleculeIGF1R agonist
nbi-6024AgonistexperimentalPeptideIGF1R agonist
proinsulin humanAgonistexperimentalRecombinant proteinIGF1R agonist
ave-1642AntagonistexperimentalmAbIGF1R antagonist
cixutumumabAntagonistexperimentalmAbIGF1R antagonist
figitumumabAntagonistexperimentalmAbIGF1R antagonist
ganitumabAntagonistexperimentalmAbIGF1R antagonist
ibi311AntagonistexperimentalmAbIGF1R
mk-0646AntagonistexperimentalmAbIGF1R antagonist
robatumumabAntagonistexperimentalmAbIGF1R antagonist
teprotumumab (Tepezza)AntagonistapprovedmAbIGF1R antagonist
vrdn-001AntagonistexperimentalmAbIGF1R
ZB001AntagonistexperimentalmAbIGF1R
cpd-1028Immunity, passiveexperimentalmAbIGF1R immunity, passive
[111in]-fpi-1547InhibitorexperimentalmAbIGF1R inhibitor
[225ac]-fpi-1434InhibitorexperimentalmAbIGF1R inhibitor
aew-541InhibitorexperimentalSmall moleculeIGF1R inhibitor
ave-1642InhibitorexperimentalmAbIGF1R inhibitor
biib-022InhibitorexperimentalmAbIGF1R inhibitor
bms754807InhibitorexperimentalSmall moleculeIGF1R inhibitor
cixutumumabInhibitorexperimentalmAbIGF1R inhibitor
figitumumabInhibitorexperimentalmAbIGF1R inhibitor
ganitumabInhibitorexperimentalmAbIGF1R inhibitor
kw-2450InhibitorexperimentalSmall moleculeIGF1R inhibitor
linsitinibInhibitorexperimentalSmall moleculeIGF1R inhibitor
lonigutamabInhibitorexperimentalmAbIGF1R inhibitor
masoprocol (actinex)InhibitorapprovedSmall moleculeIGF1R inhibitor
mhb018aInhibitorexperimentalRecombinant proteinIGF1R inhibitor
mk-0646InhibitorexperimentalmAbIGF1R inhibitor
mm-141InhibitorexperimentalmAbIGF1R inhibitor
ntb003InhibitorexperimentalmAbIGF1R inhibitor
picropodophyllinInhibitorexperimentalSmall moleculeIGF1R inhibitor
pl-225bInhibitorexperimentalSmall moleculeIGF1R inhibitor
robatumumabInhibitorexperimentalmAbIGF1R inhibitor
vrdn-003InhibitorexperimentalmAbIGF1R inhibitor
w0101InhibitorexperimentalmAbIGF1R inhibitor
xl228InhibitorexperimentalSmall moleculeIGF1R inhibitor
68ga-nodaga-zigf-1r:4RadiodepletionexperimentalmAbIGF1R radiodepletion
insulin 287SupplementationexperimentalRecombinant proteinIGF1R supplementation
insulin 320SupplementationexperimentalRecombinant proteinIGF1R supplementation
insulin 338SupplementationexperimentalRecombinant proteinIGF1R supplementation
insulin degludec (tresiba)SupplementationapprovedRecombinant proteinIGF1R supplementation
insulin detemir (Levemir)SupplementationapprovedRecombinant proteinIGF1R supplementation
insulin glargine (toujeo)SupplementationapprovedRecombinant proteinIGF1R supplementation
insulin icodecSupplementationexperimentalRecombinant proteinIGF1R supplementation
insulin lispro (humalog)SupplementationapprovedRecombinant proteinIGF1R supplementation
insulin tregopilSupplementationexperimentalRecombinant proteinIGF1R supplementation
insulin-like growth factor-binding protein-3SupplementationexperimentalRecombinant proteinIGF1R supplementation
mk-2640SupplementationexperimentalRecombinant proteinIGF1R supplementation
nnc0268-0965SupplementationexperimentalRecombinant proteinIGF1R supplementation