picropodophyllin
Small moleculeexperimental
Clinical trial activity
5 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2008 (NCT01062620)
Timeline
Indications
Studied for
- Adenocarcinoma of Lung · Phase 2
- Astrocytoma · Phase 1/Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Squamous Cell · Phase 2
- Ependymoma · Phase 1/Phase 2
- Glioblastoma · Phase 1/Phase 2
- Gliosarcoma · Phase 1/Phase 2
- Hematologic Neoplasms · Phase 1
- Neoplasms · Phase 1
- Oligodendroglioma · Phase 1/Phase 2
Mechanism of action
IGF1R inhibitor
Allosteric inhibitor, thought to inhibit IGFR1 by interfering with phosphorylation of the kinase domain A-loop at a site distinct form ATP-binidng site.
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@@H]23)OCO4)cc(OC)c1OC- Mol. weight
- 414.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL283120 ↗
Also known as
- axl1717
- axl1717
- axl1717
- axl-1717
- axl-1717
- cyclolignan ppp
- picropodophyllin
- picropodophyllin
- picropodophyllin
- picropodophyllin
- picro-podophyllin
- picropodophyllotoxin
- picropodophyllotoxin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01721577 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2012 | Axelar AB, Rush University |
| NCT01725555 | Phase 1 | Oct 1, 2012 | Axelar AB, Uppsala University |
| NCT01561456 | Phase 2 | Dec 1, 2011 | Axelar AB, Uppsala University |
| NCT01466647 | Phase 1 | Jan 1, 2011 | Axelar AB, Uppsala University |
| NCT01062620 | Phase 1 | Apr 1, 2008 | Axelar AB, Uppsala University |
Showing 5 of 5 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Axelar AB | For profit | 5 | 4 | 2 | 2008 |
| Uppsala University | Academic/Hospital | 4 | 0 | 2 | 2008 |
| Rush University | Academic/Hospital | 1 | 1 | 1 | 2012 |
3 organizations
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