← Mechanisms of action
TEK
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase TIE-2 ChEMBL ↗
Linked proteins
Drugs acting on this target (13)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| av-001 | Activator | experimental | Peptide | TEK activator |
| mucopolysaccharide polysulphate | Activator | experimental | Small molecule | TEK activator |
| altiratinib | Inhibitor | experimental | Small molecule | TEK inhibitor |
| amg-780 | Inhibitor | experimental | mAb | TEK inhibitor |
| ce-245677 | Inhibitor | experimental | Small molecule | TEK inhibitor |
| cep-11981 | Inhibitor | experimental | Small molecule | TEK inhibitor |
| esk981 | Inhibitor | experimental | Small molecule | TEK inhibitor |
| foretinib | Inhibitor | experimental | Small molecule | TEK inhibitor |
| glesatinib | Inhibitor | experimental | Small molecule | TEK inhibitor |
| mgdc265 | Inhibitor | experimental | Small molecule | TEK inhibitor |
| pexmetinib | Inhibitor | experimental | Small molecule | TEK inhibitor |
| regorafenib (stivarga) | Inhibitor | approved | Small molecule | TEK inhibitor |
| vandetanib (caprelsa) | Inhibitor | approved | Small molecule | TEK inhibitor |