ce-245677
Small moleculeexperimental
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Mechanism of action
- Tyrosine-protein kinase TIE-2INHIBITOR
TEK inhibitor
Also potent inhibitor of NTRK1 and NTRK2
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(C(=O)c2cn(C(C)C)c3ncnc(N)c23)cc1NC(=O)Nc1ccc(Cl)cc1Cl- Mol. weight
- 513.39 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3910075 ↗
- ChEMBLCHEMBL3545120 ↗
Also known as
- ce-245677