← Mechanisms of action
CRL4(CRBN) E3 ubiquitin ligase
PROTEIN COMPLEXHomo sapiens
Linked proteins
Drugs acting on this target (8)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| lenalidomide (revlimid) | Antagonist | approved | Small molecule | CRL4(CRBN) E3 ubiquitin ligase antagonist |
| cal056 | Inhibitor | experimental | Small molecule | CRL4(CRBN) E3 ubiquitin ligase inhibitor |
| lenalidomide (revlimid) | Inhibitor | approved | Small molecule | CRL4(CRBN) E3 ubiquitin ligase inhibitor |
| pomalidomide (pomalyst) | Inhibitor | approved | Small molecule | CRL4(CRBN) E3 ubiquitin ligase inhibitor |
| thalidomide (Thalomid) | Inhibitor | approved | Small molecule | CRL4(CRBN) E3 ubiquitin ligase inhibitor |
| cc-90009 | Modulator | experimental | Small molecule | CRL4(CRBN) E3 ubiquitin ligase modulator |
| Iberdomide | Modulator | experimental | Small molecule | CRL4(CRBN) E3 ubiquitin ligase modulator |
| kpg-818 | Modulator | experimental | Small molecule | CRL4(CRBN) E3 ubiquitin ligase modulator |