← Mechanisms of action
RPE65
SINGLE PROTEINHomo sapiens
Preferred name: Retinoid isomerohydrolase ChEMBL ↗
Linked proteins
Drugs acting on this target (11)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| voretigene neparvovec (Luxturna) | Exogenous gene | approved | Gene therapy | Retinoid isomerohydrolase exogenous gene |
| emixustat | Inhibitor | experimental | Small molecule | RPE65 inhibitor |
| aav2/5 optirpe65 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| ft-001 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| hg004 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| lx101 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| raav2-cb-hrpe65 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| raav2-cbsb-hrpe65 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| raav2/4.hrpe65 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| tgaag76 | Supplementation | experimental | Gene therapy | RPE65 supplementation |
| voretigene neparvovec (Luxturna) | Supplementation | approved | Gene therapy | RPE65 supplementation |