emixustat
Emixustat is a small molecule notable for its establishment of a new class of compounds known as visual cycle modulators (VCMs). Formulated as the hydrochloride salt, emixustat hydrochloride, it is the first synthetic medicinal compound shown to affect retinal disease processes when taken by mouth. Emixustat was invented by the British-American chemist, Ian L. Scott, and is currently in Phase 3 trials for dry, age-related macular degeneration (AMD). — Wikipedia
Clinical trial activity
8 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2008 (NCT00703183)
Timeline
Indications
Mechanism of action
- Retinoid isomerohydrolaseINHIBITOR
RPE65 inhibitor
Nonretinoid compound with a unique mode of action in the retinal pigment epithelium, where it modulates the biosynthesis of visual chromophore through its effect on retinal pigment epithelium-specific 65 kDa protein isomerase.
Chemistry & pharmacology
SMILES
NCC[C@@H](O)c1cccc(OCC2CCCCC2)c1- Mol. weight
- 263.38 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2107821 ↗
- WikipediaEmixustat ↗
- ChEMBLCHEMBL2107829 ↗
Also known as
- acu-4429
- acu-4429
- acu-4429
- emixustat
- emixustat
- emixustat
- emixustat
- emixustat
- emixustat hcl
- emixustat hcl
- emixustat hydrochloride
- emixustat hydrochloride
- emixustat hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03772665 | Phase 3 | Nov 7, 2018 | Acucela Inc. |
| NCT03033108 | Phase 2 | Jan 1, 2017 | Acucela Inc. |
| NCT02753400 | Phase 2 | Apr 1, 2016 | Acucela Inc. |
| NCT02130531 | Phase 1 | Apr 1, 2014 | Acucela Inc. |
| NCT01802866 | Phase 2/Phase 3 (Phase 3) | Feb 1, 2013 | Acucela Inc., Otsuka |
| NCT01002950 | Phase 2 | Oct 1, 2009 | Acucela Inc., Otsuka |
| NCT00942240 | Phase 1 | Jul 1, 2009 | Acucela Inc., Covance, Otsuka |
| NCT00703183 | Phase 1 | May 1, 2008 | Acucela Inc., Covance |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Acucela Inc. | For profit | 8 | 8 | 3 | 2008 |
| Otsuka | For profit | 3 | 0 | 3 | 2009 |
| Covance | For profit | 2 | 0 | 1 | 2008 |